ICCAS OpenIR
Determination of dissociation constants of aristolochic acid I and II by capillary electrophoresis with carboxymethyl chitosan-coated capillary
Fu, Xiaofang; Liu, Yi; Li, Wei; Bai, Yu; Liao, Yiping; Liu, Huwei
2011-07-15
Source PublicationTALANTA
ISSN0039-9140
Volume85Issue:1Pages:813-815
AbstractAristolochic acid-I and aristolochic acid-II have been proved to be the main bioactive and toxic component in Aristolochia plants. As a result, the determination of their dissociation constants, which are important property parameters for weak acids, is highly desired for related pharmacological and toxicological studies. In this work, the dissociation constant values of aristolochic acid-I and aristolochic acid-II were determined by capillary electrophoresis using carboxymethyl chitosan-coated capillary, based on their electrophoretic mobilities by using nonlinear regression as well as linear regression, showing that the two models give comparable results. The data were also compared with those obtained by capillary electrophoresis with polybrene-coated capillary, and no conspicuous difference was observed. The correlation coefficients were all higher than 0.998 for both linear and nonlinear regression model. The pKa values were found to be 3.3 +/- 0.1 for aristolochic acid-I and 3.2 +/- 0.1 for aristolochic acid-II. (C) 2011 Elsevier B.V. All rights reserved.
KeywordDissociation Constant Carboxymethyl Chitosan Capillary Coating Capillary Electrophoresis Aristolochic Acid
DOI10.1016/j.talanta.2011.03.088
Indexed BySCI
Language英语
WOS IDWOS:000292848900117
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/73158
Collection中国科学院化学研究所
Corresponding AuthorLiu, Huwei
AffiliationPeking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci,Inst Analyt Chem, Key Lab Bioorgan Chem & Mol Engn Minist Educ, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Fu, Xiaofang,Liu, Yi,Li, Wei,et al. Determination of dissociation constants of aristolochic acid I and II by capillary electrophoresis with carboxymethyl chitosan-coated capillary[J]. TALANTA,2011,85(1):813-815.
APA Fu, Xiaofang,Liu, Yi,Li, Wei,Bai, Yu,Liao, Yiping,&Liu, Huwei.(2011).Determination of dissociation constants of aristolochic acid I and II by capillary electrophoresis with carboxymethyl chitosan-coated capillary.TALANTA,85(1),813-815.
MLA Fu, Xiaofang,et al."Determination of dissociation constants of aristolochic acid I and II by capillary electrophoresis with carboxymethyl chitosan-coated capillary".TALANTA 85.1(2011):813-815.
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