ICCAS OpenIR
pH-Regulated transfer hydrogenation of quinoxalines with a Cp*Ir-diamine catalyst in aqueous media
Tan, Jing1; Tang, Weijun1,3; Sun, Yawei2; Jiang, Zhen1; Chen, Fei2; Xu, Lijin1,2; Fan, Qinghua2; Xiao, Jianliang3
2011-08-26
Source PublicationTETRAHEDRON
ISSN0040-4020
Volume67Issue:34Pages:6206-6213
AbstractThe combination of [Cp*IrCl(2)](2) with N-(2-aminoethyl)-4-(trifluoromethyl)benzenesulfonamide constitutes an efficient catalyst for selective transfer hydrogenation of a variety of quinoxalines in water with HCOONa as the hydrogen source, affording the corresponding tetrahydroquinoxalines in good to excellent yields. The catalyst is air-stable, and the reduction could be performed without nitrogen protection. The aqueous phase reduction is shown to be highly pH-dependent, with acidic pH leading to better results. There exits a pH window for optimum rate, and the use of HOAc/NaOAc buffer solution is essential for maintaining a stable pH during the reaction. (C) 2011 Elsevier Ltd. All rights reserved.
KeywordTransfer Hydrogenation Ph Quinoxaline Iridium Tetrahydroquinoxaline
DOI10.1016/j.tet.2011.06.067
Indexed BySCI ; IC ; CCR
Language英语
WOS IDWOS:000293493900013
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/73030
Collection中国科学院化学研究所
Corresponding AuthorXu, Lijin
Affiliation1.Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China
2.Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
3.Univ Liverpool, Dept Chem, Liverpool Ctr Mat & Catalysis, Liverpool L69 7ZD, Merseyside, England
Recommended Citation
GB/T 7714
Tan, Jing,Tang, Weijun,Sun, Yawei,et al. pH-Regulated transfer hydrogenation of quinoxalines with a Cp*Ir-diamine catalyst in aqueous media[J]. TETRAHEDRON,2011,67(34):6206-6213.
APA Tan, Jing.,Tang, Weijun.,Sun, Yawei.,Jiang, Zhen.,Chen, Fei.,...&Xiao, Jianliang.(2011).pH-Regulated transfer hydrogenation of quinoxalines with a Cp*Ir-diamine catalyst in aqueous media.TETRAHEDRON,67(34),6206-6213.
MLA Tan, Jing,et al."pH-Regulated transfer hydrogenation of quinoxalines with a Cp*Ir-diamine catalyst in aqueous media".TETRAHEDRON 67.34(2011):6206-6213.
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