Synthesis and immunomodulatory activity of [60]fullerene-tuftsin conjugates
Xu, Yingying1; Zhu, Jiadan1; Xiang, Kun1; Li, Yuankai1; Sun, Ronghua1; Ma, Jie2; Sun, Hongfang1; Liu, Yuanfang1,3
Source PublicationBIOMATERIALS
AbstractImmunomodulating peptide tuftsin (Thr-Lys-Pro-Arg) was covalently conjugated to fullerene C(60) by two different ways to prepare NH(2)-tuftsin-C(60) and C(60)-tuftsin-COOH. The two new compounds were intensively characterized. The synthetic C(60)-tuftsin conjugates were assayed for their stability against leucine aminopeptidase degradation. And the immunostimulating activities to murine peritoneal macrophages were investigated in vitro. Compared with the natural tuftsin, significant enhancement of phagocytosis, chemotaxis activities and major histocompatibility complex class II (MHC II) molecule expression were observed in macrophages stimulated by both of the conjugates. The two conjugates also exhibit complete resistance to enzymatic hydrolysis, and they are non-toxic to macrophages in the tested concentrations. On all accounts, these results suggest that the C(60)-tuftsin conjugates can be used as potential candidates of immunomodulators and vaccine adjuvants. (C) 2011 Elsevier Ltd. All rights reserved.
KeywordFullerene c(60) Tuftsin Peritoneal Macrophages Phagocytosis Chemotaxis Mhc Ii
Indexed BySCI
WOS IDWOS:000296821800039
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Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorSun, Hongfang
Affiliation1.Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Chinese Acad Med Sci, Inst Canc, State Key Lab Mol Oncol, PUMC, Beijing 100021, Peoples R China
3.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
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GB/T 7714
Xu, Yingying,Zhu, Jiadan,Xiang, Kun,et al. Synthesis and immunomodulatory activity of [60]fullerene-tuftsin conjugates[J]. BIOMATERIALS,2011,32(36):9940-9949.
APA Xu, Yingying.,Zhu, Jiadan.,Xiang, Kun.,Li, Yuankai.,Sun, Ronghua.,...&Liu, Yuanfang.(2011).Synthesis and immunomodulatory activity of [60]fullerene-tuftsin conjugates.BIOMATERIALS,32(36),9940-9949.
MLA Xu, Yingying,et al."Synthesis and immunomodulatory activity of [60]fullerene-tuftsin conjugates".BIOMATERIALS 32.36(2011):9940-9949.
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