ICCAS OpenIR
Electrospinning fabrication, structural and mechanical characterization of rod-like virus-based composite nanofibers
Wu, Laying2,3,4,5; Zang, Jianfeng1; Lee, L. Andrew2,3; Niu, Zhongwei6; Horvatha, Gary C.2,3; Braxtona, Vaughn2,3; Wibowo, Arief Cahyo2,3; Bruckman, Michael A.2,3; Ghoshroy, Soumitra4,5; zur Loye, Hans-Conrad2,3; Li, Xiaodong1; Wang, Qian2,3
2011
Source PublicationJOURNAL OF MATERIALS CHEMISTRY
ISSN0959-9428
Volume21Issue:24Pages:8550-8557
AbstractTobacco mosaic virus (TMV) was electrospun with polyvinyl alcohol (PVA) into continuous TMV-PVA composite nanofibers to form a biodegradable nonwoven fibrous mat as an extracellular matrix (ECM) mimetic. Morphological characterizations by electron microscopy showed that the addition of varying amounts of TMV resulted in homogeneous nanofibers without phase separation and did not change the diameter of the composite nanofibers. The orientation of TMV in as-spun fibers could be readily controlled and post-processing of the nonwoven TMV-PVA mat significantly improved its water resistance. In addition, tensile tests were performed on individual nanofibers, which revealed that the TMV-PVA composite nanofibers achieved a comparable Young's modulus as PVA nanofibers. Since the modification of TMV is readily achieved via genetic or chemical methods, this process offers a facile way to incorporate a variety of functionalities into polymer nanofibers. As a demonstration of its potential as ECM mimetic, a mutant TMV containing RGD peptide was co-spun with PVA and the resulting fibrous substrates were used to promote cell growth.
DOI10.1039/c1jm00078k
Indexed BySCI
Language英语
WOS IDWOS:000291352900012
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72986
Collection中国科学院化学研究所
Corresponding AuthorLi, Xiaodong
Affiliation1.Univ S Carolina, Dept Mech Engn, Columbia, SC 29208 USA
2.Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA
3.Univ S Carolina, Nanoctr, Columbia, SC 29208 USA
4.Univ S Carolina, Elect Microscopy Ctr, Columbia, SC 29208 USA
5.Univ S Carolina, Dept Biol Sci, Columbia, SC 29208 USA
6.Chinese Acad Sci, Inst Chem & Phys, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wu, Laying,Zang, Jianfeng,Lee, L. Andrew,et al. Electrospinning fabrication, structural and mechanical characterization of rod-like virus-based composite nanofibers[J]. JOURNAL OF MATERIALS CHEMISTRY,2011,21(24):8550-8557.
APA Wu, Laying.,Zang, Jianfeng.,Lee, L. Andrew.,Niu, Zhongwei.,Horvatha, Gary C..,...&Wang, Qian.(2011).Electrospinning fabrication, structural and mechanical characterization of rod-like virus-based composite nanofibers.JOURNAL OF MATERIALS CHEMISTRY,21(24),8550-8557.
MLA Wu, Laying,et al."Electrospinning fabrication, structural and mechanical characterization of rod-like virus-based composite nanofibers".JOURNAL OF MATERIALS CHEMISTRY 21.24(2011):8550-8557.
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