Programmable DNA switch for bioresponsive controlled release

doi:10.1039/c1jm12203g

ICCAS OpenIR

	Programmable DNA switch for bioresponsive controlled release
	Chen, Linfeng 1; Wen, Yongqiang 1; Su, Bin 1; Di, Jiancheng 2; Song, Yanlin 1; Jiang, Lei 1
	2011
Source Publication	JOURNAL OF MATERIALS CHEMISTRY
ISSN	0959-9428
Volume	21 Issue:36 Pages:13811-13816
Abstract	A bioresponsive controlled release system based on mesoporous silica nanoparticles (MS) was designed and constructed. Through the DNAa/DANb assembly, DNAb-modified gold nanoparticles (AuNPs-DNAb) could be attached to the pores of MS covalently functionalized with DNAa. In the presence of adenosine, the pores of MS could be opened and the encapsulated guest was released, due to the interaction between DNAb and adenosine. Forster resonance energy transfer (FRET) was used to confirm the switching mechanism. Furthermore, the carry system was exclusively responsive to adenosine, and the process was dependent on the concentration of adenosine, which made the system promising for target-directing controlled release.
DOI	10.1039/c1jm12203g
Indexed By	SCI
Language	英语
WOS ID	WOS:000294441300014
Publisher	ROYAL SOC CHEMISTRY
Citation statistics	Cited Times:35[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.iccas.ac.cn/handle/121111/72846
Collection	中国科学院化学研究所
Corresponding Author	Wen, Yongqiang
Affiliation	1.Chinese Acad Sci, Inst Chem, New Mat Lab, Key Lab Organ Solids,BNLMS, Beijing 100190, Peoples R China 2.Jilin Univ, Coll Chem, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Peoples R China
Recommended Citation GB/T 7714	Chen, Linfeng,Wen, Yongqiang,Su, Bin,et al. Programmable DNA switch for bioresponsive controlled release[J]. JOURNAL OF MATERIALS CHEMISTRY,2011,21(36):13811-13816.
APA	Chen, Linfeng,Wen, Yongqiang,Su, Bin,Di, Jiancheng,Song, Yanlin,&Jiang, Lei.(2011).Programmable DNA switch for bioresponsive controlled release.JOURNAL OF MATERIALS CHEMISTRY,21(36),13811-13816.
MLA	Chen, Linfeng,et al."Programmable DNA switch for bioresponsive controlled release".JOURNAL OF MATERIALS CHEMISTRY 21.36(2011):13811-13816.

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