ICCAS OpenIR
Programmable DNA switch for bioresponsive controlled release
Chen, Linfeng1; Wen, Yongqiang1; Su, Bin1; Di, Jiancheng2; Song, Yanlin1; Jiang, Lei1
2011
Source PublicationJOURNAL OF MATERIALS CHEMISTRY
ISSN0959-9428
Volume21Issue:36Pages:13811-13816
AbstractA bioresponsive controlled release system based on mesoporous silica nanoparticles (MS) was designed and constructed. Through the DNAa/DANb assembly, DNAb-modified gold nanoparticles (AuNPs-DNAb) could be attached to the pores of MS covalently functionalized with DNAa. In the presence of adenosine, the pores of MS could be opened and the encapsulated guest was released, due to the interaction between DNAb and adenosine. Forster resonance energy transfer (FRET) was used to confirm the switching mechanism. Furthermore, the carry system was exclusively responsive to adenosine, and the process was dependent on the concentration of adenosine, which made the system promising for target-directing controlled release.
DOI10.1039/c1jm12203g
Indexed BySCI
Language英语
WOS IDWOS:000294441300014
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:35[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72846
Collection中国科学院化学研究所
Corresponding AuthorWen, Yongqiang
Affiliation1.Chinese Acad Sci, Inst Chem, New Mat Lab, Key Lab Organ Solids,BNLMS, Beijing 100190, Peoples R China
2.Jilin Univ, Coll Chem, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Peoples R China
Recommended Citation
GB/T 7714
Chen, Linfeng,Wen, Yongqiang,Su, Bin,et al. Programmable DNA switch for bioresponsive controlled release[J]. JOURNAL OF MATERIALS CHEMISTRY,2011,21(36):13811-13816.
APA Chen, Linfeng,Wen, Yongqiang,Su, Bin,Di, Jiancheng,Song, Yanlin,&Jiang, Lei.(2011).Programmable DNA switch for bioresponsive controlled release.JOURNAL OF MATERIALS CHEMISTRY,21(36),13811-13816.
MLA Chen, Linfeng,et al."Programmable DNA switch for bioresponsive controlled release".JOURNAL OF MATERIALS CHEMISTRY 21.36(2011):13811-13816.
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