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Preparation and aggregation behavior of mannose-terminated poly(ethylene glycol)-b-poly(L-leucine) in water
Wang, Rui; Chen, Gunag-Tao; Du, Fu-Sheng; Li, Zi-Chen
2011-06-15
Source PublicationCOLLOIDS AND SURFACES B-BIOINTERFACES
ISSN0927-7765
Volume85Issue:1Pages:56-62
AbstractAmphiphilic diblock copolymers composed of poly(ethylene glycol) (PEG) and poly(L-leucine) (PLeu) with mannose at the chain end of PEG were synthesized by a combination of ring-opening polymerization (ROP) and click chemistry. First, an alpha-azido, omega-amino PEG (N(3)-PEG-NH(2)) was synthesized and converted to the corresponding amine hydrochloride (N(3)-PEG-NH(2 center dot)HCl), which was used as a macroinitiator to initiate the ROP of L-leucine-N-carboxyanhydride (Leu-NCA), yielding three amphiphilic block copolymers with different chain lengths of PLeu (N(3)-PEG-b-PLeu). Then, click chemistry of the alkynyl mannose with N(3)-PEG-b-PLeu anchored a mannose moiety to the PEG chain end of the copolymer. The self-assembly behavior of these copolymers in water was investigated using transmission electron microscopy (TEM), laser light scattering (LLS) and circular dichroism (CD). Depending on the copolymer composition and the initial concentration of the copolymer in organic solvent, different morphologies (e.g. spherical micelle, wormlike micelle) were observed. The aggregation behavior was demonstrated to be controlled by secondary structure formation and the hydrophobic interactions of the PLeu segments. With mannose moieties on the surface of the aggregates, these aggregates could bind reversibly the lectin Concanavalin A (Con A). (C) 2010 Elsevier B.V. All rights reserved.
KeywordPeg Poly(L-leucine) Mannose Block Copolymer Self-assembly
DOI10.1016/j.colsurfb.2010.11.012
Indexed BySCI
Language英语
WOS IDWOS:000290196100010
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72812
Collection中国科学院化学研究所
Corresponding AuthorLi, Zi-Chen
AffiliationPeking Univ, BNLMS, Key Lab Polymer Chem & Phys, Minist Educ,Dept Polymer Sci & Engn,Coll Chem & M, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Wang, Rui,Chen, Gunag-Tao,Du, Fu-Sheng,et al. Preparation and aggregation behavior of mannose-terminated poly(ethylene glycol)-b-poly(L-leucine) in water[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2011,85(1):56-62.
APA Wang, Rui,Chen, Gunag-Tao,Du, Fu-Sheng,&Li, Zi-Chen.(2011).Preparation and aggregation behavior of mannose-terminated poly(ethylene glycol)-b-poly(L-leucine) in water.COLLOIDS AND SURFACES B-BIOINTERFACES,85(1),56-62.
MLA Wang, Rui,et al."Preparation and aggregation behavior of mannose-terminated poly(ethylene glycol)-b-poly(L-leucine) in water".COLLOIDS AND SURFACES B-BIOINTERFACES 85.1(2011):56-62.
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