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PREPARATION AND EVALUATION OF CATIONIC TC-99/TC-99M DIMETHOXY-HEXANEDIONE AND DIETHOXY-HEXANEDIONE DIOXIME COMPLEXES
SU, ZF; LINSE, KH; STEINMETZ, HJ; SCHWOCHAU, K
1992
Source PublicationJOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN0362-4803
Volume31Issue:1Pages:61-70
AbstractThe new ligands 1,6-dimethoxy-3,4-hexanedione dioxime (DMHD) and 1,6-diethoxy-3,4-hexanedione dioxime (DEHD) were synthesized and their boron containing Tc-99/Tc-99m complexes, formed by reduction of pertechnetate with BH4-, were isolated, purified and characterized by IR/UV/VIS spectroscopy and FAB mass spectrometry. These rather stable cationic complexes differ significantly in lipophilicity as assessed by their octanol/saline partition coefficients and HPLC capacity factors. Unexpectedly the organ uptake and clearance of both complexes in mice proved to be very similar with only the uptake of Tc-99m-DMHD in the kidneys being enhanced.
KeywordTechnetium Cationic Dioxime Complexes Lipophilicity Biodistribution
Indexed BySCI
Language英语
WOS IDWOS:A1992HA48900006
PublisherJOHN WILEY & SONS LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72784
Collection中国科学院化学研究所
Affiliation1.FORSCHUNGSZENTRUM JULICH, FORSCHUNGSZENTRUM, INST CHEM NUKL CHEM 1, W-5170 JULICH 1, GERMANY
2.ACAD SINICA, INST CHEM, BEIJING 100080, PEOPLES R CHINA
Recommended Citation
GB/T 7714
SU, ZF,LINSE, KH,STEINMETZ, HJ,et al. PREPARATION AND EVALUATION OF CATIONIC TC-99/TC-99M DIMETHOXY-HEXANEDIONE AND DIETHOXY-HEXANEDIONE DIOXIME COMPLEXES[J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,1992,31(1):61-70.
APA SU, ZF,LINSE, KH,STEINMETZ, HJ,&SCHWOCHAU, K.(1992).PREPARATION AND EVALUATION OF CATIONIC TC-99/TC-99M DIMETHOXY-HEXANEDIONE AND DIETHOXY-HEXANEDIONE DIOXIME COMPLEXES.JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,31(1),61-70.
MLA SU, ZF,et al."PREPARATION AND EVALUATION OF CATIONIC TC-99/TC-99M DIMETHOXY-HEXANEDIONE AND DIETHOXY-HEXANEDIONE DIOXIME COMPLEXES".JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 31.1(1992):61-70.
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