ICCAS OpenIR
Nucleic acid-modulated silver nanoparticles: A new electrochemical platform for sensing chloride ion
Jin, Jianyu1; Ouyang, Xiangyuan2; Li, Jishan2; Jiang, Jianhui2; Wang, Hao1; Wang, Yongxiang1; Yang, Ronghua1,2
2011
Source PublicationANALYST
ISSN0003-2654
Volume136Issue:18Pages:3629-3634
AbstractInorganic nanomaterials have generated considerable interest in connection to the design of biosensors. Here we exploit the DNA-induced generation of silver nanoparticles for developing an electrical biosensing protocol for chloride ions. Conjugated with thiol modified oligonucleotide, silver nanoparticles were template-synthesized and immobilized on gold electrode. During cyclic voltammogram (CV) scans, the silver nanoparticles were oxidized at high potential to form a layer of Ag/AgCl complex in the presence of Cl(-), giving off sharp solid state redox signals. Under the optimum condition, the electrode responded to Cl(-) over a dynamic range of 2.0 x 10(-5)-0.01 M, with a detection limit of 5.0 x 10(-6) M. Moreover, the specific solubility product constant-based anion recognition made the electrode applicable at a wide pH range and in complex biological systems. To demonstrate the analytical applications of this sensor in real samples, the Cl(-) concentrations in human urine were measured without any sample pretreatment. Urinary Cl(-) detected by the proposed sensor ranged from 110 to 200 mM, which was comparable to the results obtained by standard silver titration.
DOI10.1039/c1an15283a
Indexed BySCI
Language英语
WOS IDWOS:000294123300009
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72738
Collection中国科学院化学研究所
Corresponding AuthorYang, Ronghua
Affiliation1.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Hunan Univ, Coll Chem & Chem Engn, Ctr Biomed Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Jin, Jianyu,Ouyang, Xiangyuan,Li, Jishan,et al. Nucleic acid-modulated silver nanoparticles: A new electrochemical platform for sensing chloride ion[J]. ANALYST,2011,136(18):3629-3634.
APA Jin, Jianyu.,Ouyang, Xiangyuan.,Li, Jishan.,Jiang, Jianhui.,Wang, Hao.,...&Yang, Ronghua.(2011).Nucleic acid-modulated silver nanoparticles: A new electrochemical platform for sensing chloride ion.ANALYST,136(18),3629-3634.
MLA Jin, Jianyu,et al."Nucleic acid-modulated silver nanoparticles: A new electrochemical platform for sensing chloride ion".ANALYST 136.18(2011):3629-3634.
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