ICCAS OpenIR
Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials
Zhu, Yingyue1; Chen, Wei1; Qiao, Ruirui2; Wang, Libing1; Xu, Chuanlai1
2011
Source PublicationINTERNATIONAL JOURNAL OF NANOTECHNOLOGY
ISSN1475-7435
Volume8Issue:8-9Pages:664-678
AbstractIntroduction, A novel transfection vector was designed to deliver the antisense oligodeoxynucleotide into the cancer cells (HL-60). Methods, Antisense oligodeoxynucleotides (ASODNs) were conjugated to the gold nanoparticles (GNPs) through a chemical reaction. The conjugates were then bound to the single-walled carbon nanotubes (SWNTs). This vector system can effectively for induced apoptosis of the cancer cells. Results, The gold nanoparticles helped to improve both transfection and Raman signal. Conclusions, This vector system can be effective for induced apoptosis of the cancer cells, and thus has the potential to be used as a cancer therapy.
KeywordSingle-walled Carbon Nanotubes Swnts Antisense Oligodeoxynucleotides Asodns Gold Nanoparticles Gnps Transfection Vector
DOI10.1504/IJNT.2011.041437
Indexed BySCI
Language英语
WOS IDWOS:000295368600005
PublisherINDERSCIENCE ENTERPRISES LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72672
Collection中国科学院化学研究所
Corresponding AuthorXu, Chuanlai
Affiliation1.Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing 10008, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Yingyue,Chen, Wei,Qiao, Ruirui,et al. Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials[J]. INTERNATIONAL JOURNAL OF NANOTECHNOLOGY,2011,8(8-9):664-678.
APA Zhu, Yingyue,Chen, Wei,Qiao, Ruirui,Wang, Libing,&Xu, Chuanlai.(2011).Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials.INTERNATIONAL JOURNAL OF NANOTECHNOLOGY,8(8-9),664-678.
MLA Zhu, Yingyue,et al."Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials".INTERNATIONAL JOURNAL OF NANOTECHNOLOGY 8.8-9(2011):664-678.
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