ICCAS OpenIR
Light and host-guest inclusion mediated salmon sperm DNA/surfactant interactions
Lin, Yiyang1; Zhang, Yudong1; Qiao, Yan1; Huang, Jianbin1; Xu, Baocai2
2011-10-15
Source PublicationJOURNAL OF COLLOID AND INTERFACE SCIENCE
ISSN0021-9797
Volume362Issue:2Pages:430-438
AbstractDNA/cationic surfactant interaction is relevant from the viewpoint of gene therapy, where the complexation and resulting compaction are essential to protect DNA from nuclease, and to allow entry of DNA into cells. In this work, light input and host-guest inclusion controlled DNA complexation by a novel cationic surfactant 1-[6-(4-phenylazo-phenoxy)-hexyl]-3-methylimidazolium bromide (AzoC6Mim) is reported. The surfactant is covalently attached with an azobenzene group, which undergoes reversible photoisomerizations by changing light input. Under visible light, trans-AzoC6Mim can bind to salmon sperm DNA through electrostatic attraction and hydrophobic interaction, resulting into DNA compaction. Under UV light, although cis-AzoC6Mim still binds to DNA chain, DNA/surfactant complex is decompacted owing to the decrease of surfactant hydrophobicity. On the other hand, azobenzene group can form an inclusion complex with alpha-CD through host-guest interaction, which removes AzoC6Mim from DNA chain and decompacts the DNA/surfactant complex. (C) 2011 Elsevier Inc. All rights reserved.
KeywordDna Complexation Surfactant Light Host-guest Interaction Azobenzene
DOI10.1016/j.jcis.2011.06.083
Indexed BySCI
Language英语
WOS IDWOS:000294142500024
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72616
Collection中国科学院化学研究所
Corresponding AuthorHuang, Jianbin
Affiliation1.Peking Univ, BNLMS, State Key Lab Struct Chem Unstable & Stable Speci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Beijing Technol & Business Univ, Sch Chem & Environm Engn, Beijing 100037, Peoples R China
Recommended Citation
GB/T 7714
Lin, Yiyang,Zhang, Yudong,Qiao, Yan,et al. Light and host-guest inclusion mediated salmon sperm DNA/surfactant interactions[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2011,362(2):430-438.
APA Lin, Yiyang,Zhang, Yudong,Qiao, Yan,Huang, Jianbin,&Xu, Baocai.(2011).Light and host-guest inclusion mediated salmon sperm DNA/surfactant interactions.JOURNAL OF COLLOID AND INTERFACE SCIENCE,362(2),430-438.
MLA Lin, Yiyang,et al."Light and host-guest inclusion mediated salmon sperm DNA/surfactant interactions".JOURNAL OF COLLOID AND INTERFACE SCIENCE 362.2(2011):430-438.
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