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One-Pot Synthesis of Pyrrolo[3,2-d]pyridazines and Pyrrole-2,3-diones via Zirconocene-Mediated Four-Component Coupling of Si-Tethered Diyne, Nitriles, and Azide
Zhang, Shaoguang1,2; Zhao, Jing3; Zhang, Wen-Xiong1,2,4; Xi, Zhenfeng1,2
2011-04-01
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume13Issue:7Pages:1626-1629
AbstractA one-pot synthesis of pyrrolo[3,2-d]pyridazine derivatives via zirconocene-mediated four-component coupling of one Si-tethered diyne, two nitriles, and one azide is reported. When TMSN3 was used, pyrrole-2,3-diones were formed in good yields. Further condensation of these highly functionalized pyrrole-2,3-diones with hydrazine and hydroxylamine afforded useful pyrrole-fused heterocycles.
DOI10.1021/ol200038n
Indexed BySCI ; IC ; CCR
Language英语
WOS IDWOS:000288691600013
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72576
Collection中国科学院化学研究所
Corresponding AuthorXi, Zhenfeng
Affiliation1.Peking Univ, Coll Chem, Minist Educ, BNLMS, Beijing 100871, Peoples R China
2.Peking Univ, Coll Chem, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
4.Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Shaoguang,Zhao, Jing,Zhang, Wen-Xiong,et al. One-Pot Synthesis of Pyrrolo[3,2-d]pyridazines and Pyrrole-2,3-diones via Zirconocene-Mediated Four-Component Coupling of Si-Tethered Diyne, Nitriles, and Azide[J]. ORGANIC LETTERS,2011,13(7):1626-1629.
APA Zhang, Shaoguang,Zhao, Jing,Zhang, Wen-Xiong,&Xi, Zhenfeng.(2011).One-Pot Synthesis of Pyrrolo[3,2-d]pyridazines and Pyrrole-2,3-diones via Zirconocene-Mediated Four-Component Coupling of Si-Tethered Diyne, Nitriles, and Azide.ORGANIC LETTERS,13(7),1626-1629.
MLA Zhang, Shaoguang,et al."One-Pot Synthesis of Pyrrolo[3,2-d]pyridazines and Pyrrole-2,3-diones via Zirconocene-Mediated Four-Component Coupling of Si-Tethered Diyne, Nitriles, and Azide".ORGANIC LETTERS 13.7(2011):1626-1629.
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