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| Improving the blood clearance time of I-125 labeled Dex-g-PMAGGCONHTyr by copolymerization | |
| Wang, Deqian1,2; Liu, Ruigang1; Che, Ning1,2; Li, Qinmei1,2; Li, Zhuang1,2; Tian, Ye1,2; Kang, Honglang1; Jia, Bing3; Huang, Yong1,4 | |
| 2011 | |
| Source Publication | POLYMER CHEMISTRY
 |
| ISSN | 1759-9954 |
| Volume | 2Issue:8Pages:1872-1878 |
| Abstract | Dextran graft copolymers, including dextran graft poly(N-methacryloylglycylglycine) copolymers conjugated with polyethylene glycol and tyrosine (Dex-g-PMAGGCONHPEG(3k)-NHTyr), dextran graft poly(N-(2-hydroxypropyl) methacrylamide-co-N-methacryloylglycylglycine)-tyrosine conjugates (Dex-g-P(HPMA-co-MAGGCONHTyr)), and dextran graft poly(methacrylpolyethylene glycol-co-N-methacryloylglycylglycine)-tyrosine conjugates (Dex-g-P(MPEG-co-MAGGCONHTyr)) were synthesized for the purpose to improve the biodistribution and blood clearance time of ploy(N-methacryloylglycylglycine)-tyrosine conjugates (Dex-g-PMAGGCONHTyr). Dynamic light scattering (DLS) results indicated that no aggregation formed in 0.9% saline solution. The graft copolymers were labeled with I-125 and the labeled copolymers are stable in 0.9% saline and 1% BSA of PBS solutions. Pharmacokinetics studies showed that I-125 labeled graft copolymer Dex-g-P(HPMA-co-MAGGCONHTyr) had a longer blood clearance time than the others. Biodistribution images confirmed the preferable liver and spleen accumulation at 1 h after injection, and especially for blood tissue, the mean %ID/g value of the PHPMA-modified graft copolymer Dex-g-P(HPMA-co-MAGGCONHTyr) is 7 folds higher than that of Dex-g-PMAGGCONHTyr. |
| DOI | 10.1039/c1py00168j |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000292965500036 |
| Publisher | ROYAL SOC CHEMISTRY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.iccas.ac.cn/handle/121111/72552 |
| Collection | 中国科学院化学研究所 |
| Corresponding Author | Liu, Ruigang |
| Affiliation | 1.Chinese Acad Sci, Inst Chem, Lab Polymer Phys & Chem, Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China 3.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China 4.Chinese Acad Sci, Tech Inst Phys & Chem, Natl Res Ctr Engn Plast, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Deqian,Liu, Ruigang,Che, Ning,et al. Improving the blood clearance time of I-125 labeled Dex-g-PMAGGCONHTyr by copolymerization[J]. POLYMER CHEMISTRY,2011,2(8):1872-1878. |
| APA | Wang, Deqian.,Liu, Ruigang.,Che, Ning.,Li, Qinmei.,Li, Zhuang.,...&Huang, Yong.(2011).Improving the blood clearance time of I-125 labeled Dex-g-PMAGGCONHTyr by copolymerization.POLYMER CHEMISTRY,2(8),1872-1878. |
| MLA | Wang, Deqian,et al."Improving the blood clearance time of I-125 labeled Dex-g-PMAGGCONHTyr by copolymerization".POLYMER CHEMISTRY 2.8(2011):1872-1878. |
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