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Dual Molecular Light Switches for pH and DNA Based on a Novel Ru(II) Complex. A Non-Intercalating Ru(II) Complex for DNA Molecular Light Switch
Zhang, An-Guo1; Zhang, You-Zhuan1; Duan, Zhi-Ming1; Wang, Ke-Zhi1; Wei, Hui-Bo2; Bian, Zu-Qiang2; Huang, Chun-Hui2
2011-07-18
Source PublicationINORGANIC CHEMISTRY
ISSN0020-1669
Volume50Issue:14Pages:6425-6436
AbstractA new Ru(II) complex of [Ru(phen)(2)(Hcdpq)](ClO(4))(2) {phen = 1,10-phenanthroline, Hcdpq = 2-carboxyl-dipyrido[3,2-f:2',3'-h]quinoxaline} was synthesized and characterized. The spectrophotometric pH and calf thymus DNA (ct-DNA) titrations showed that the complex acted as a dual molecular light switch for pH and ct-DNA with emission enhancement factors of 17 and 26, respectively. It was shown to be capable of distinguishing ct-DNA from yeast RNA with this binding selectivity being superior to two well-known DNA molecular light switches of [Ru(bpy)(2)(dppz)](2+) {bpy =2,2'-bipyridine, and dppz = dipyrido-[3,2-a:2',3'-c]phenazine} and ethidium bromide. The complex bond to ct-DNA probably in groove mode with a binding constant of (4.67 +/- 0.06) x 10(3) M(-1) in 5 mM Tris-HCl, 50 mM NaCl (pH = 7.10) buffer solution, as evidenced by UV-visible absorption and luminescence titrations, the dependence of DNA binding constants on NaCl concentrations, DNA competitive binding with ethidium bromide, and emission lifetime and viscosity measurements. To get insight into the light-switch mechanism, theoretical calculations were also performed by applying density functional theory (DFT) and time-dependent DFT.
DOI10.1021/ic102126m
Indexed BySCI
Language英语
WOS IDWOS:000292618000007
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:56[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72518
Collection中国科学院化学研究所
Corresponding AuthorWang, Ke-Zhi
Affiliation1.Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China
2.Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, State Key Lab Rare Earth Mat Chem & Applicat, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zhang, An-Guo,Zhang, You-Zhuan,Duan, Zhi-Ming,et al. Dual Molecular Light Switches for pH and DNA Based on a Novel Ru(II) Complex. A Non-Intercalating Ru(II) Complex for DNA Molecular Light Switch[J]. INORGANIC CHEMISTRY,2011,50(14):6425-6436.
APA Zhang, An-Guo.,Zhang, You-Zhuan.,Duan, Zhi-Ming.,Wang, Ke-Zhi.,Wei, Hui-Bo.,...&Huang, Chun-Hui.(2011).Dual Molecular Light Switches for pH and DNA Based on a Novel Ru(II) Complex. A Non-Intercalating Ru(II) Complex for DNA Molecular Light Switch.INORGANIC CHEMISTRY,50(14),6425-6436.
MLA Zhang, An-Guo,et al."Dual Molecular Light Switches for pH and DNA Based on a Novel Ru(II) Complex. A Non-Intercalating Ru(II) Complex for DNA Molecular Light Switch".INORGANIC CHEMISTRY 50.14(2011):6425-6436.
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