ICCAS OpenIR
Improve the Strength of PLA/HA Composite Through the Use of Surface Initiated Polymerization and Phosphonic Acid Coupling Agent
Wang, Tongxin1,2; Chow, Laurence C.3; Frukhtbeyn, Stanislav A.3; Ting, Andy Hai1; Dong, Quanxiao1,2,4; Yang, Mingshu4; Mitchell, James W.1
2011-09-01
Source PublicationJOURNAL OF RESEARCH OF THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
ISSN1044-677X
Volume116Issue:5Pages:785-796
AbstractBioresorbable composite made from degradable polymers, e. g., polylactide (PLA), and bioactive calcium phosphates, e. g., hydroxyapatite (HA), are clinically desirable for bone fixation, repair and tissue engineering because they do not need to be removed by surgery after the bone heals. However, preparation of PLA/HA composite from non-modified HA usually results in mechanical strength reductions due to a weak interface between PLA and HA. In this study, a calcium-phosphate/phosphonate hybrid shell was developed to introduce a greater amount of reactive hydroxyl groups onto the HA particles. Then, PLA was successfully grafted on HA by surface-initiated polymerization through the non-ionic surface hydroxyl groups. Thermogravimetric analysis indiated that the amount of grafted PLA on HA can be up to 7 %, which is about 50 % greater than that from the literature. PLA grafted HA shows significantly different pH dependent zeta-potential and particle size profiles from those of uncoated HA. By combining the phosphonic acid coupling agent and surface initiated polymerization, PLA could directly link to HA through covalent bond so that the interfacial interaction in the PLA/HA composite can be significantly improved. The diametral tensile strength of PLA/HA composite prepared from PLA-grafted HA was found to be over twice that of the composite prepared from the non-modified HA. Moreover, the tensile strength of the improved composite was 23 % higher than that of PLA alone. By varying additional variables, this approach has the potential to produce bioresorbable composites with improved mechanical properties that are in the range of natural bones, and can have wide applications for bone fixation and repair in load-bearing areas.
KeywordBioresorbable Composite Hydroxyapatite Interface Mechanical Pla Polymerization
DOI10.6028/jres.116.021
Indexed BySCI
Language英语
WOS IDWOS:000295866500004
PublisherUS GOVERNMENT PRINTING OFFICE
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72494
Collection中国科学院化学研究所
Corresponding AuthorWang, Tongxin
Affiliation1.Howard Univ, Coll Engn, Washington, DC 20059 USA
2.Howard Univ, Coll Dent, Washington, DC 20059 USA
3.Natl Inst Stand & Technol, Div Polymer, Paffenbarger Res Ctr, Amer Dent Assoc Fdn, Gaithersburg, MD 20899 USA
4.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wang, Tongxin,Chow, Laurence C.,Frukhtbeyn, Stanislav A.,et al. Improve the Strength of PLA/HA Composite Through the Use of Surface Initiated Polymerization and Phosphonic Acid Coupling Agent[J]. JOURNAL OF RESEARCH OF THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY,2011,116(5):785-796.
APA Wang, Tongxin.,Chow, Laurence C..,Frukhtbeyn, Stanislav A..,Ting, Andy Hai.,Dong, Quanxiao.,...&Mitchell, James W..(2011).Improve the Strength of PLA/HA Composite Through the Use of Surface Initiated Polymerization and Phosphonic Acid Coupling Agent.JOURNAL OF RESEARCH OF THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY,116(5),785-796.
MLA Wang, Tongxin,et al."Improve the Strength of PLA/HA Composite Through the Use of Surface Initiated Polymerization and Phosphonic Acid Coupling Agent".JOURNAL OF RESEARCH OF THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY 116.5(2011):785-796.
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