Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization

doi:10.1021/bm1013662

ICCAS OpenIR

	Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization
	Guo, Jinshan 1; Wei, Ying 1; Zhou, Dongfang 1; Cai, Pingqiang 2; Jing, Xiabin 1; Chen, Xue-Si 1; Huang, Yubin 1
	2011-03-01
Source Publication	BIOMACROMOLECULES
ISSN	1525-7797
Volume	12 Issue:3 Pages:737-746
Abstract	Poly(epsilon-lysine) (epsilon-PL)-analogous click polypeptides with not only similar alpha-amino side groups but also similar main chain to epsilon-PL were chemically synthesized for the first time though click polymerization from aspartic (or glutamic)-acid-based dialkyne and diazide monomers. With microwave-assisting, the reaction time of click polymerization was compressed into 30 min. The polymers were fully characterized by NMR, ATR-FTIR, and SEC-MALLS analysis. The deprotected click polypeptides had similar pK(a) value (7.5) and relatively low cytotoxicity as epsilon-PL and could be used as substitutes of epsilon-PL in biomedical applications, especially in endotoxin selective removal. Poly(ethylene glycol) (PEG)-containing alternating copolymers with a-amino groups were also synthesized and characterized. After deprotection, the polymers could be used as functional gene vector with PEG shadowing system and NCA initiator to get amphiphilic graft polymers.
DOI	10.1021/bm1013662
Indexed By	SCI ; IC ; CCR
Language	英语
WOS ID	WOS:000288183100027
Publisher	AMER CHEMICAL SOC
Citation statistics	Cited Times:37[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.iccas.ac.cn/handle/121111/72472
Collection	中国科学院化学研究所
Corresponding Author	Huang, Yubin
Affiliation	1.Chinese Acad Sci, Changchun Inst Appl Chem, Grad Sch, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Jilin Univ, Dept Mat Sci & Engn, Changchun 130022, Peoples R China
Recommended Citation GB/T 7714	Guo, Jinshan,Wei, Ying,Zhou, Dongfang,et al. Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization[J]. BIOMACROMOLECULES,2011,12(3):737-746.
APA	Guo, Jinshan.,Wei, Ying.,Zhou, Dongfang.,Cai, Pingqiang.,Jing, Xiabin.,...&Huang, Yubin.(2011).Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization.BIOMACROMOLECULES,12(3),737-746.
MLA	Guo, Jinshan,et al."Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization".BIOMACROMOLECULES 12.3(2011):737-746.

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