ICCAS OpenIR
Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization
Guo, Jinshan1; Wei, Ying1; Zhou, Dongfang1; Cai, Pingqiang2; Jing, Xiabin1; Chen, Xue-Si1; Huang, Yubin1
2011-03-01
Source PublicationBIOMACROMOLECULES
ISSN1525-7797
Volume12Issue:3Pages:737-746
AbstractPoly(epsilon-lysine) (epsilon-PL)-analogous click polypeptides with not only similar alpha-amino side groups but also similar main chain to epsilon-PL were chemically synthesized for the first time though click polymerization from aspartic (or glutamic)-acid-based dialkyne and diazide monomers. With microwave-assisting, the reaction time of click polymerization was compressed into 30 min. The polymers were fully characterized by NMR, ATR-FTIR, and SEC-MALLS analysis. The deprotected click polypeptides had similar pK(a) value (7.5) and relatively low cytotoxicity as epsilon-PL and could be used as substitutes of epsilon-PL in biomedical applications, especially in endotoxin selective removal. Poly(ethylene glycol) (PEG)-containing alternating copolymers with a-amino groups were also synthesized and characterized. After deprotection, the polymers could be used as functional gene vector with PEG shadowing system and NCA initiator to get amphiphilic graft polymers.
DOI10.1021/bm1013662
Indexed BySCI ; IC ; CCR
Language英语
WOS IDWOS:000288183100027
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72472
Collection中国科学院化学研究所
Corresponding AuthorHuang, Yubin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, Grad Sch, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Jilin Univ, Dept Mat Sci & Engn, Changchun 130022, Peoples R China
Recommended Citation
GB/T 7714
Guo, Jinshan,Wei, Ying,Zhou, Dongfang,et al. Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization[J]. BIOMACROMOLECULES,2011,12(3):737-746.
APA Guo, Jinshan.,Wei, Ying.,Zhou, Dongfang.,Cai, Pingqiang.,Jing, Xiabin.,...&Huang, Yubin.(2011).Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization.BIOMACROMOLECULES,12(3),737-746.
MLA Guo, Jinshan,et al."Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization".BIOMACROMOLECULES 12.3(2011):737-746.
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