ICCAS OpenIR
Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene
Lin, Sen2; Li, Sufang1; Chen, Zan1; He, Xiangwei1; Zhang, Youyi1; Xu, Xiaojie2; Xu, Ming1; Yuan, Gu2
2011-10-01
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume21Issue:19Pages:5987-5991
AbstractG-Quadruplexes have been proved to exist in 5'-untranslated region (5'-UTR), promoter, intron and exon regions of many human genes. Here we report an intramolecular G-quadruplex formed by a G-rich sequence in the 3'-flanking region of signal transducers and activators of transcription 3 (STAT3) gene. The results showed that this G-rich sequence could affect the expression of STAT3. When the STAT3 G-quadruplex was stabilized by a novel non-planar ligand Cepharanthine (CEP), the decreased expression of STAT3 was observed in primary cultured cardiomyocytes. We also demonstrated that the down-regulation of STAT3 was most likely occurred at the transcriptional level. Our results provide a new clue for studying the G-quadruplex formation, recognition and function in the 3'-flanking region of gene. (C) 2011 Elsevier Ltd. All rights reserved.
KeywordG-quadruplex 3'-flanking Region Cepharanthine Stat3 Gene Gene Regulation
DOI10.1016/j.bmcl.2011.07.121
Indexed BySCI
Language英语
WOS IDWOS:000294714400071
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72456
Collection中国科学院化学研究所
Corresponding AuthorXu, Ming
Affiliation1.Peking Univ, Inst Vasc Med, Hosp 3, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Natl Lab Mol Sci BNLMS, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Lin, Sen,Li, Sufang,Chen, Zan,et al. Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(19):5987-5991.
APA Lin, Sen.,Li, Sufang.,Chen, Zan.,He, Xiangwei.,Zhang, Youyi.,...&Yuan, Gu.(2011).Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(19),5987-5991.
MLA Lin, Sen,et al."Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.19(2011):5987-5991.
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