ICCAS OpenIR
Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals
Zhou, Jia-Cai1; Yang, Zheng-Lin2; Dong, Wei2; Tang, Ruo-Jin1; Sun, Ling-Dong1; Yan, Chun-Hua1
2011-12-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume32Issue:34Pages:9059-9067
AbstractIn vitro or in vivo bioimaging utilizing the upconversion (UC) luminescence of rare earth fluoride nanocrystals (NCs) has attracted much attention, especially for Yb3+/Tm3+ doped NCs with a near-infrared (NIR) UC emission at 800 nm. Herein, water-soluble NaYF4:Yb,Tm NCs with strong NIR UC emission were synthesized with a solvothermal method. In vitro and in vivo bioimaging and toxicity assessments were carried out with HeLa cell and Caenorhabditis elegans (C. elegans) cases, respectively. NaYF4:Yb,Tm NCs afforded an efficient NIR image of the HeLa cells with an incubation concentration of 10 mu g mL(-1), and CCK-8 assay revealed a low cytotoxicity. Fed with Escherichia coli (E. coli) and NCs together, the C elegans showed a NIR image in the gut from the pharynx to the anus. Further, these NCs could be excreted out when those worms were then fed with only E. Coli Toxicity studies were further addressed with protein expression, life span, egg production, egg viability, and growth rate of the worms in comparison with those of the intact ones. The feeding of rare earth fluoride NCs with a dose of 100 mu g does not arise obvious toxicity effect from the growth to procreation. The in vitro and in vivo studies confirm that NaYF4:Yb,Tm NCs could be served as an excellent NIR emission bioprobe with low toxicity. (C) 2011 Elsevier Ltd. All rights reserved.
KeywordNear-infrared Emission Bioimaging Toxicity Assessments In Vitro In Vivo Nayf4:Yb Tm Nanocrystals
DOI10.1016/j.biomaterials.2011.08.038
Indexed BySCI
Language英语
WOS IDWOS:000296113500030
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:175[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72208
Collection中国科学院化学研究所
Corresponding AuthorSun, Ling-Dong
Affiliation1.Peking Univ, State Key Lab Rare Earth Mat Chem & Applicat, PKU HKU Joint Lab Rare Earth Mat & Bioinorgan Che, Beijing Natl Lab Mol Sci,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Jia-Cai,Yang, Zheng-Lin,Dong, Wei,et al. Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals[J]. BIOMATERIALS,2011,32(34):9059-9067.
APA Zhou, Jia-Cai,Yang, Zheng-Lin,Dong, Wei,Tang, Ruo-Jin,Sun, Ling-Dong,&Yan, Chun-Hua.(2011).Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals.BIOMATERIALS,32(34),9059-9067.
MLA Zhou, Jia-Cai,et al."Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals".BIOMATERIALS 32.34(2011):9059-9067.
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