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Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs
Gu, Jingxia2; Cheng, Woei Ping1; Hoskins, Clare3; Lin, Paul Kong Thoo3; Zhao, Lingling2; Zhu, Lijun2; Qu, Xiaozhong2; Yang, Zhenzhong2
2011
Source PublicationJOURNAL OF MICROENCAPSULATION
ISSN0265-2048
Volume28Issue:8Pages:752-762
AbstractThe physicochemical compatibility between amphiphilic polymers and hydrophobic drugs has been recognized as an important issue for improving the drug solubilisation in polymeric micelle formulations. In this work, poly-L-lysine (PLL) grafted by cholate pendants as the only hydrophobic moiety were synthesized in order to facilitate the solubilisation of sterol drugs. Results showed that micelles formed by cholate grafted PLL encapsulated significantly higher level of prednisolone and estradiol than palmitoylated PLL micelles, whereas the solubilisation capacity of non-sterol drug (griseofulvin) is inefficient for both polymers. This suggests that higher drug-polymer incorporation can be achieved by the inclusion of hydrophobic moieties with similar architecture as the drugs, i.e. 'drug-like' functional groups, which will be useful for the future design of colloidal systems for the encapsulation of specific drug.
KeywordDrug Solubilisation Amphiphilic Graft Copolymer Micelle Drug-polymer Interaction
DOI10.3109/02652048.2011.615951
Indexed BySCI
Language英语
WOS IDWOS:000297353300007
PublisherINFORMA HEALTHCARE
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72204
Collection中国科学院化学研究所
Corresponding AuthorCheng, Woei Ping
Affiliation1.Univ Hertfordshire, Sch Pharm, Hatfield AL10 9AB, Herts, England
2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China
3.Robert Gordon Univ, Sch Pharm & Life Sci, Aberdeen AB10 1FR, Scotland
Recommended Citation
GB/T 7714
Gu, Jingxia,Cheng, Woei Ping,Hoskins, Clare,et al. Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs[J]. JOURNAL OF MICROENCAPSULATION,2011,28(8):752-762.
APA Gu, Jingxia.,Cheng, Woei Ping.,Hoskins, Clare.,Lin, Paul Kong Thoo.,Zhao, Lingling.,...&Yang, Zhenzhong.(2011).Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs.JOURNAL OF MICROENCAPSULATION,28(8),752-762.
MLA Gu, Jingxia,et al."Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs".JOURNAL OF MICROENCAPSULATION 28.8(2011):752-762.
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