ICCAS OpenIR
Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models
Wan, Yanhui2; Zheng, Yonghui1; Song, Xiangfu3; Hu, Xiuli1; Liu, Shi1; Tong, Ti2; Jing, Xiabin1
2011
Source PublicationJOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
ISSN0920-5063
Volume22Issue:9Pages:1131-1146
AbstractTwo kinds of paclitaxel (PTX) conjugate nanomicelles were prepared for cell apoptosis and anti-tumor activity evaluation on Lewis lung cancer mice models. One (PTX micelles) was prepared by self-assembling the PTX-conjugate co-polymer, poly(ethylene glycol)-b-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate/PTX), and the other (FA-PTX micelles) was by co-assembling a mixture of the folic acid (FA)-carrying co-polymer poly(ethylene glycol)-b-poly(L-lactide-co-2,2-dihydroxylmethyl-propylene carbonate/FA) (PEG-b-P(LA-co-DHP/FA)), and the PTX-conjugate co-polymer. At 7 and 14 days after tail intravenous injection, the mice were killed. The inhibition rates of tumor growth for PTX and FA-PTX micelles were 50 and 90%, respectively, on the day 7, and 33 and 71%, respectively, on the day 14 after drug injection. Flow cytometry analysis showed that the cell apoptosis rates were 43, 54 and 72% for the control group, PTX micelles group and FA-PTX micelles group, respectively, on the day 7, and 16, 25 and 42 on the day 14. With the TUNEL assay, the grey values of PTX micelles and FA-PTX micelles groups were determined to be 61-62% and 43-44%, of that of the control group, on day 7 or day 14, respectively. Therefore, the PTX micelles and the FA-PTX composite micelles significantly inhibited the subcutaneously inoculated Lewis lung cancer and effectively induced the cell apoptosis, and the FA-PTX composite micelles displayed a better efficacy than the PTX-micelles, implying the contribution of the folate-mediated targeting and endocytosis effect. (C) Koninklijke Brill NV, Leiden, 2011
KeywordLewis Lung Cancer Polymer-drug Conjugate Paclitaxel Folic Acid Targeted Drug Delivery Cell Apoptosis
DOI10.1163/092050610X500570
Indexed BySCI
Language英语
WOS IDWOS:000288135600002
PublisherVSP BV
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72152
Collection中国科学院化学研究所
Corresponding AuthorJing, Xiabin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Jilin Univ, Hosp 1, Changchun 130021, Peoples R China
3.Jilin Univ, Sch Publ Hlth, Changchun 130021, Peoples R China
Recommended Citation
GB/T 7714
Wan, Yanhui,Zheng, Yonghui,Song, Xiangfu,et al. Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,2011,22(9):1131-1146.
APA Wan, Yanhui.,Zheng, Yonghui.,Song, Xiangfu.,Hu, Xiuli.,Liu, Shi.,...&Jing, Xiabin.(2011).Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models.JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,22(9),1131-1146.
MLA Wan, Yanhui,et al."Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models".JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 22.9(2011):1131-1146.
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