ICCAS OpenIR
Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies
Mao, Xiao-Bo1; Wang, Chen-Xuan1,2; Wu, Xing-Kui1; Ma, Xiao-Jing1,3; Liu, Lei1; Zhang, Lan1; Niu, Lin1; Guo, Yuan-Yuan1; Li, Deng-Hua1; Yang, Yan-Lian1; Wang, Chen1
2011-12-06
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
Volume108Issue:49Pages:19605-19610
AbstractWe report here the identification of the key sites for the beta structure motifs of the islet amyloid polypeptide (IAPP) analogs by using scanning tunneling microscopy (STM). Duplex folding structures in human IAPP(8-37) (hIAPP(8-37)) assembly were observed featuring a hairpin structure. The multiplicity in rIAPP assembly structures indicates the polydispersity of the rat IAPP(8-37) (rIAPP(8-37)) beta-like motifs. The bimodal length distribution of beta structure motifs for rIAPP(8-37) R18H indicates the multiple beta segments linked by turns. The IAPP(8-37) analogs share common structure motifs of IAPP(8-17) and IAPP(26-37) with the most probable key sites at positions around Ser(19)/Ser(20) and Gly(24). These observations reveal the similar amyloid formation tendency in the C and N terminus segments because of the sequence similarity, while the differences in specific amino acids at each key site manifest the effect of sequence variations. The results could be beneficial for studying structural polymorphism of amyloidal peptides with multiple beta structure motifs.
KeywordAmylin Folding Sites Self-assembly Amyloid
DOI10.1073/pnas.1102971108
Indexed BySCI
Language英语
WOS IDWOS:000297683800040
PublisherNATL ACAD SCIENCES
Citation statistics
Cited Times:47[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72148
Collection中国科学院化学研究所
Corresponding AuthorYang, Yan-Lian
Affiliation1.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
2.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
Recommended Citation
GB/T 7714
Mao, Xiao-Bo,Wang, Chen-Xuan,Wu, Xing-Kui,et al. Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2011,108(49):19605-19610.
APA Mao, Xiao-Bo.,Wang, Chen-Xuan.,Wu, Xing-Kui.,Ma, Xiao-Jing.,Liu, Lei.,...&Wang, Chen.(2011).Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,108(49),19605-19610.
MLA Mao, Xiao-Bo,et al."Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108.49(2011):19605-19610.
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