ICCAS OpenIR
Anti-tumor Metastasis and Crystal Structure of N-1-(1,3,4-Thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea
Zou Xia-Juan1; Zhang Shi-Wei2; Liu Ying2; Liu Zheng-Ming2; Gao Jun-Wei3; Song Qian-Liu3; Pan Yan3; Zhang Jian-Zhao3; Li Xue-Jun3
2011
Source PublicationCHINESE JOURNAL OF STRUCTURAL CHEMISTRY
ISSN0254-5861
Volume30Issue:7Pages:1001-1005
AbstractThe title compound N-1-(1,3,4-thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea (C9H7N4OSCl, M-r = 254.70) was prepared by the reaction of m-chlorophenyl isocyanate with 2-amino-1,3,4-thiadiazole in dry acetonitrile. The effect of the title compound on tumor metastasis was analyzed by Lewis-lung-carcinoma model. The bioassay showed that the title compound significantly reduced the number of lung metastasis. The crystal structure has been determined by X-ray diffraction. The crystal belongs to the monoclinic system, space group P2(1)/c with a = 11.565(2), b = 9.5616(19), c = 10.221(2) angstrom, beta = 111.75(3)degrees, Z = 4, V = 1049.8(4) angstrom(3), D-c = 1.612 Mg/m(3), F(000) = 520, mu(MoKa) = 0.544 mm(-1), R = 0.0468 and wR = 0.0922 for 1236 observed reflections (I > 2 sigma(I)).
KeywordCrystal Structure Anti-tumor Metastasis Lewis-lung-carcinoma Model Synthesis 2-amino-1 3 4-thiadiazole Derivatives
Indexed BySCI
Language英语
WOS IDWOS:000293676600011
PublisherCHINESE JOURNAL STRUCTURAL CHEMISTRY
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72112
Collection中国科学院化学研究所
Corresponding AuthorZou Xia-Juan
Affiliation1.Peking Univ, Med & Healthy Analyt Ctr, Prote Lab, Beijing 100191, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zou Xia-Juan,Zhang Shi-Wei,Liu Ying,et al. Anti-tumor Metastasis and Crystal Structure of N-1-(1,3,4-Thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,2011,30(7):1001-1005.
APA Zou Xia-Juan.,Zhang Shi-Wei.,Liu Ying.,Liu Zheng-Ming.,Gao Jun-Wei.,...&Li Xue-Jun.(2011).Anti-tumor Metastasis and Crystal Structure of N-1-(1,3,4-Thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea.CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,30(7),1001-1005.
MLA Zou Xia-Juan,et al."Anti-tumor Metastasis and Crystal Structure of N-1-(1,3,4-Thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea".CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 30.7(2011):1001-1005.
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