ICCAS OpenIR
Drug-target network and polypharmacology studies of a Traditional Chinese Medicine for type II diabetes mellitus
Gu, Jiangyong1; Zhang, Hu1,2; Chen, Lirong1; Xu, Shun2; Yuan, Gu1; Xu, Xiaojie1
2011-10-12
Source PublicationCOMPUTATIONAL BIOLOGY AND CHEMISTRY
ISSN1476-9271
Volume35Issue:5Pages:293-297
AbstractMany Traditional Chinese Medicines (TCMs) are effective to relieve complicated diseases such as type II diabetes mellitus (T2DM). In this work, molecular docking and network analysis were employed to elucidate the action mechanism of a medical composition which had clinical efficacy for T2DM. We found that multiple active compounds contained in this medical composition would target multiple proteins related to T2DM and the biological network would be shifted. We predicted the key players in the medical composition and some of them have been reported in literature. Meanwhile, several compounds such as Rheidin A, Rheidin C, Sennoside C, procyanidin Cl and Dihydrobaicalin were notable although no one have reported their pharmacological activity against T2DM. The association between active compounds, target proteins and other diseases was also discussed. (c) 2011 Elsevier Ltd. All rights reserved.
KeywordType Ii Diabetes Network Analysis Virtual Screening Traditional Chinese Medicine Drug-target Network Polypharmacology
DOI10.1016/j.compbiolchem.2011.07.003
Indexed BySCI
Language英语
WOS IDWOS:000296930400004
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:45[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72098
Collection中国科学院化学研究所
Corresponding AuthorXu, Xiaojie
Affiliation1.Peking Univ, Beijing Natl Lab Mol Sci, State Key Lab Rare Earth Mat Chem & Applicat, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Zhengzhou Univ, Dept Chem, Zhengzhou 450052, Peoples R China
Recommended Citation
GB/T 7714
Gu, Jiangyong,Zhang, Hu,Chen, Lirong,et al. Drug-target network and polypharmacology studies of a Traditional Chinese Medicine for type II diabetes mellitus[J]. COMPUTATIONAL BIOLOGY AND CHEMISTRY,2011,35(5):293-297.
APA Gu, Jiangyong,Zhang, Hu,Chen, Lirong,Xu, Shun,Yuan, Gu,&Xu, Xiaojie.(2011).Drug-target network and polypharmacology studies of a Traditional Chinese Medicine for type II diabetes mellitus.COMPUTATIONAL BIOLOGY AND CHEMISTRY,35(5),293-297.
MLA Gu, Jiangyong,et al."Drug-target network and polypharmacology studies of a Traditional Chinese Medicine for type II diabetes mellitus".COMPUTATIONAL BIOLOGY AND CHEMISTRY 35.5(2011):293-297.
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