ICCAS OpenIR
Synthesis and Characterization of Chitosan-Albumin Conjugates as pH-Sensitive Biodegradable Hydrogels
Guo Jin-shan1,2; Li Jian-zheng3; Jing Xia-bin1; Chen Xue-si1; Huang Yu-bin1
2011-03-01
Source PublicationCHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN1005-9040
Volume27Issue:2Pages:329-333
AbstractA new kind of biodegradable pH-sensitive drug delivery system was developed via chitosan-albumin conjugate hydrogel. Through changing the feeding modes of reactants, two types of hydrogels(comb-type and reticular-type) were synthesized by amidation reactions between 6-O-succinoylated N-phthaloyl chitosan and albumin. The structures and morphologies of the hydrogels were characterized by SEM. And their water swelling capacity, drug loading and releasing properties at different pH values were also investigated. It was found that the comb-type of hydrogels with looser space construction had better water swelling ratio(more than 400% of its original mass) than the reticular-type of ones did(about 180% of its original mass). In vitro release experiments of Rifampicin show that the hydrogels provided the controlled release of the entrapped drug for more than 50 h. The drug release rates of both types of hydrogels under acidic condition were lower than those under neutral or basic condition. The introduction of albumin not only improved the hydrophilicity of chitosan, but also provided the possibility of the carrier system combining other biologically active materials more easily to fulfill the delivery and therapy functions.
KeywordChitosan Albumin Hydrogel Ph Sensitive Drug Delivery
Indexed BySCI
Language英语
WOS IDWOS:000290001800038
PublisherHIGHER EDUCATION PRESS
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72042
Collection中国科学院化学研究所
Corresponding AuthorHuang Yu-bin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Jilin Univ, Dept Mat Sci & Engn, Changchun 130022, Peoples R China
Recommended Citation
GB/T 7714
Guo Jin-shan,Li Jian-zheng,Jing Xia-bin,et al. Synthesis and Characterization of Chitosan-Albumin Conjugates as pH-Sensitive Biodegradable Hydrogels[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2011,27(2):329-333.
APA Guo Jin-shan,Li Jian-zheng,Jing Xia-bin,Chen Xue-si,&Huang Yu-bin.(2011).Synthesis and Characterization of Chitosan-Albumin Conjugates as pH-Sensitive Biodegradable Hydrogels.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,27(2),329-333.
MLA Guo Jin-shan,et al."Synthesis and Characterization of Chitosan-Albumin Conjugates as pH-Sensitive Biodegradable Hydrogels".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 27.2(2011):329-333.
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