ICCAS OpenIR
A novel dendritic surfactant for enhanced microcystin-LR detection by double amplification in a quartz crystal microbalance biosensor
Xia, Yuetong; Zhang, Jianping; Jiang, Long
2011-08-01
Source PublicationCOLLOIDS AND SURFACES B-BIOINTERFACES
ISSN0927-7765
Volume86Issue:1Pages:81-86
AbstractEnhanced sensitivity for the hepatotoxin microcystin-LR (MC-LR) was achieved in a quartz crystal microbalance (QCM) system via double amplification. For primary amplification, an innovative interface on the QCM was obtained as a matrix by the vesicle layer formed by our synthetic dendritic surfactant, bin (amidoethyl-carbamoylethyl) octadecylamine (C18N3). The vesicle matrix was then functionalised by an optimised concentration of monoclonal antibodies against MC-LR (anti-MC-LR) to detect the analyte. The results showed that a detection limit of 100 ng/mL was achieved by primary amplification. To achieve higher sensitivity, secondary amplification was implemented with anti-MC-LR gold nanoparticle (AuNPs) conjugates as probes, which lowered the detection limit for MC-LR to 1 ng/mL (the maximum concentration recommended by the World Health Organization [WHO] in drinking water for humans). The QCM immunosensor reported here has advantages such as high sensitivity, portability, simplicity, and cost-effectiveness for MC-LR detection. It would be uniquely superior compared with current MC-LR detection techniques for on-the-spot water detection. Furthermore, the methodology described here is also potentially significant in many fields for the routine monitoring of environmental and food safety. (C) 2011 Elsevier B.V. All rights reserved.
KeywordMicrocystin-lr Quartz Crystal Microbalance Dendritic Surfactant Vesicle Array Double Amplification
DOI10.1016/j.colsurfb.2011.03.019
Indexed BySCI
Language英语
WOS IDWOS:000291458100011
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/72014
Collection中国科学院化学研究所
Corresponding AuthorJiang, Long
AffiliationChinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xia, Yuetong,Zhang, Jianping,Jiang, Long. A novel dendritic surfactant for enhanced microcystin-LR detection by double amplification in a quartz crystal microbalance biosensor[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2011,86(1):81-86.
APA Xia, Yuetong,Zhang, Jianping,&Jiang, Long.(2011).A novel dendritic surfactant for enhanced microcystin-LR detection by double amplification in a quartz crystal microbalance biosensor.COLLOIDS AND SURFACES B-BIOINTERFACES,86(1),81-86.
MLA Xia, Yuetong,et al."A novel dendritic surfactant for enhanced microcystin-LR detection by double amplification in a quartz crystal microbalance biosensor".COLLOIDS AND SURFACES B-BIOINTERFACES 86.1(2011):81-86.
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