ICCAS OpenIR
Chemo-Physical and Biological Evaluation of Poly( L-lysine)-Grafted Chitosan Copolymers Used for Highly Efficient Gene Delivery
Yu, Haijun; Deng, Chao; Tian, Huayu; Lu, Tiancheng; Chen, Xuesi; Jing, Xiabin
2011-03-10
Source PublicationMACROMOLECULAR BIOSCIENCE
ISSN1616-5187
Volume11Issue:3Pages:352-361
AbstractFor the success of non-viral gene delivery, it is of great importance to develop gene vectors with high efficiency but low toxicity. We demonstrate that PLL-grafted chitosan copolymers combine the advantages of PLL with its good pDNA-binding ability and of chitosan with its good biocompatibility. The chemo-physical properties of the prepared Chi-g-PLL copolymers are thoroughly characterized. The in vitro transfection study shows that the copolymers have a much higher gene transfer ability than the starting materials chitosan and PLL. A positive correlation between PLL chain lengths and transfection efficiency of the copolymers is found. Our results suggest that these novel Chi-g-PLL copolymers are good candidates for gene delivery in vivo.
KeywordChitosan Gene Delivery Graft Copolymers Non-viral Poly(L-lysine)
DOI10.1002/mabi.201000283
Indexed BySCI
Language英语
WOS IDWOS:000288034800005
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/71978
Collection中国科学院化学研究所
Corresponding AuthorJing, Xiabin
AffiliationChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
Recommended Citation
GB/T 7714
Yu, Haijun,Deng, Chao,Tian, Huayu,et al. Chemo-Physical and Biological Evaluation of Poly( L-lysine)-Grafted Chitosan Copolymers Used for Highly Efficient Gene Delivery[J]. MACROMOLECULAR BIOSCIENCE,2011,11(3):352-361.
APA Yu, Haijun,Deng, Chao,Tian, Huayu,Lu, Tiancheng,Chen, Xuesi,&Jing, Xiabin.(2011).Chemo-Physical and Biological Evaluation of Poly( L-lysine)-Grafted Chitosan Copolymers Used for Highly Efficient Gene Delivery.MACROMOLECULAR BIOSCIENCE,11(3),352-361.
MLA Yu, Haijun,et al."Chemo-Physical and Biological Evaluation of Poly( L-lysine)-Grafted Chitosan Copolymers Used for Highly Efficient Gene Delivery".MACROMOLECULAR BIOSCIENCE 11.3(2011):352-361.
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