ICCAS OpenIR
Preparation of Novel Trolox-chitosan Nanoparticles and Its Anti-oxidation Activity
Han Lu; Du Li-Bo; Jia Hong-Ying; Tian Qin; Liu Yang
2011-05-10
Source PublicationCHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN0251-0790
Volume32Issue:5Pages:1013-1015
AbstractAntioxidants are restricted for extensive application because of their disadvantages, including poor solubility and unsatisfactory bioavailabilty. Herein, Trolox, an analogue of vitamin E, was firstly encapsulated into chitosan nanoparticles, which were prepared by self-assembling method. The UV-Vis spectrophotometer and atom force microscope were used to characterize Trolox-chitosan nanoparticles. The results show that the uniform sizes of Trolox-chitosan nanoparticles were about 20-40 tins, and the solubility of Trolox was increased about 27 times. Moreover, the anti-oxidation activity of Trolox-chitosan nanoparticles was evaluated by methods of MTT reduction and MDA content detection. It was revealed that Trolox-chitosan nanoparticles showed better ability of protecting RAW264.7 cells from oxidative stress induced by t-BHP than Trolox alone at the same concentration. The present study demonstrated a new strategy for elevating the solubility of antioxidants or drugs and improving their bioavailability by virtue of loading or conjugating them onto nanoparticles.
KeywordChitosan Nanoparticle Trolox Anti-oxidation Activity
Indexed BySCI
Language英语
WOS IDWOS:000291175800004
PublisherHIGHER EDUCATION PRESS
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/71956
Collection中国科学院化学研究所
Corresponding AuthorLiu Yang
AffiliationChinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Han Lu,Du Li-Bo,Jia Hong-Ying,et al. Preparation of Novel Trolox-chitosan Nanoparticles and Its Anti-oxidation Activity[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2011,32(5):1013-1015.
APA Han Lu,Du Li-Bo,Jia Hong-Ying,Tian Qin,&Liu Yang.(2011).Preparation of Novel Trolox-chitosan Nanoparticles and Its Anti-oxidation Activity.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,32(5),1013-1015.
MLA Han Lu,et al."Preparation of Novel Trolox-chitosan Nanoparticles and Its Anti-oxidation Activity".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 32.5(2011):1013-1015.
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