ICCAS OpenIR
Studies of the Interactions between Three Protoberberine Alkaloids and Bcl-2 by Fluorescence Spectroscopy
Zhang Yanxia1,2; Zhang Xiufeng1; Tang Yalin1; Xiang Junfeng1; Tian Mingyue1,3
2011-01-28
Source PublicationACTA CHIMICA SINICA
ISSN0567-7351
Volume69Issue:2Pages:247-251
AbstractThe interactions between Bcl-2 and three protoberberine alkaloids: berberine hydrochloride, jatrorrhizine and palmatine hydrochloride were studied by fluorescence spectroscopy. The binding constants and the number of binding sites were measured, respectively, and the quenching mechanism was proposed. The results indicated that the protoberberine alkaloids could decrease the intrinsic fluorescence of Bcl-2 mainly through static quenching. By comparing the structures of the three alkaloids, it was found that the binding affinity to Bcl-2 protein increased with molecular flexibility of the alkaloids.
KeywordBerberine Hydrochloride Jatrorrhizine Palmatine Hydrochloride Bcl-2 Fluorescence Spectroscopy
Indexed BySCI
Language英语
WOS IDWOS:000287907800023
PublisherSCIENCE CHINA PRESS
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/71918
Collection中国科学院化学研究所
Corresponding AuthorZhang Yanxia
Affiliation1.Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Beijing Normal Univ, Coll Life Sci, Beijing 100875, Peoples R China
Recommended Citation
GB/T 7714
Zhang Yanxia,Zhang Xiufeng,Tang Yalin,et al. Studies of the Interactions between Three Protoberberine Alkaloids and Bcl-2 by Fluorescence Spectroscopy[J]. ACTA CHIMICA SINICA,2011,69(2):247-251.
APA Zhang Yanxia,Zhang Xiufeng,Tang Yalin,Xiang Junfeng,&Tian Mingyue.(2011).Studies of the Interactions between Three Protoberberine Alkaloids and Bcl-2 by Fluorescence Spectroscopy.ACTA CHIMICA SINICA,69(2),247-251.
MLA Zhang Yanxia,et al."Studies of the Interactions between Three Protoberberine Alkaloids and Bcl-2 by Fluorescence Spectroscopy".ACTA CHIMICA SINICA 69.2(2011):247-251.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang Yanxia]'s Articles
[Zhang Xiufeng]'s Articles
[Tang Yalin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang Yanxia]'s Articles
[Zhang Xiufeng]'s Articles
[Tang Yalin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang Yanxia]'s Articles
[Zhang Xiufeng]'s Articles
[Tang Yalin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.