ICCAS OpenIR
Amphiphilic Cationic [Dendritic poly(L-lysine)]-block-poly(L-lactide)-block-[dendritic poly(L-lysine)]s in Aqueous Solution: Self-Aggregation and Interaction with DNA as Gene Delivery Carriers
Zhu, Yingdan; Sheng, Ruilong; Luo, Ting; Li, Hui; Sun, Wenyan; Li, Yang; Cao, Amin
2011-02-11
Source PublicationMACROMOLECULAR BIOSCIENCE
ISSN1616-5187
Volume11Issue:2Pages:174-186
AbstractA new series of triblock [dendritic poly(L-lysine)]-block-PLLA-block-[dendritic poly(L-lysine)]s(DL(2)-PLLA-DL(2)) with PLLA block lengths of 11.5-26.5 and double 2-generation PLL dendrons DL(2) as model cationic amphiphiles were synthesized and characterized. Their CAC, self-aggregation and plasmid DNA binding affinities in pure water and PBS were studied. The PLLA block length dependence of particle size, morphology and xi potential for organized pDNA/amphiphile polyplex aggregates were examined. Finally, toxicities of these DL(2)-PLLA-DL(2) amphiphiles and their polyplexes were assayed by MTT with HeLa, SMMC-7721 and COS-7 cells, and COS-7 cell luciferase and eGFP gene transfection efficacies with these amphiphiles as the delivery carriers were investigated.
KeywordAmphiphiles Biocompatibility Biological Applications Of Polymers Drug Delivery Systems Synthesis
DOI10.1002/mabi.201000225
Indexed BySCI
Language英语
WOS IDWOS:000287162800002
PublisherWILEY-BLACKWELL
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/71784
Collection中国科学院化学研究所
Corresponding AuthorCao, Amin
AffiliationChinese Acad Sci, Shanghai Inst Organ Chem, Polymer Mat Lab, Shanghai 200032, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Yingdan,Sheng, Ruilong,Luo, Ting,et al. Amphiphilic Cationic [Dendritic poly(L-lysine)]-block-poly(L-lactide)-block-[dendritic poly(L-lysine)]s in Aqueous Solution: Self-Aggregation and Interaction with DNA as Gene Delivery Carriers[J]. MACROMOLECULAR BIOSCIENCE,2011,11(2):174-186.
APA Zhu, Yingdan.,Sheng, Ruilong.,Luo, Ting.,Li, Hui.,Sun, Wenyan.,...&Cao, Amin.(2011).Amphiphilic Cationic [Dendritic poly(L-lysine)]-block-poly(L-lactide)-block-[dendritic poly(L-lysine)]s in Aqueous Solution: Self-Aggregation and Interaction with DNA as Gene Delivery Carriers.MACROMOLECULAR BIOSCIENCE,11(2),174-186.
MLA Zhu, Yingdan,et al."Amphiphilic Cationic [Dendritic poly(L-lysine)]-block-poly(L-lactide)-block-[dendritic poly(L-lysine)]s in Aqueous Solution: Self-Aggregation and Interaction with DNA as Gene Delivery Carriers".MACROMOLECULAR BIOSCIENCE 11.2(2011):174-186.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhu, Yingdan]'s Articles
[Sheng, Ruilong]'s Articles
[Luo, Ting]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhu, Yingdan]'s Articles
[Sheng, Ruilong]'s Articles
[Luo, Ting]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhu, Yingdan]'s Articles
[Sheng, Ruilong]'s Articles
[Luo, Ting]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.