ICCAS OpenIR
Fabrication and biological application of nano-hydroxyapatite (nHA)/alginate (ALG) hydrogel as scaffolds
Du, Mingchun1; Song, Weixing2; Cui, Yue1; Yang, Yang2; Li, Junbai1
2011
Source PublicationJOURNAL OF MATERIALS CHEMISTRY
ISSN0959-9428
Volume21Issue:7Pages:2228-2236
AbstractWe have fabricated tubular hydrogel scaffolds of nano-hydroxyapatite (nHA)/alginate (ALG) via a layer-by-layer (LbL) technique. Using Ca2+ as a crosslinker, nHA was assembled with ALG to form a hydrogel network. The inner diameter of scaffolds could be controlled from 0.5 mm to 7 mm by varying the assembled layer numbers of nHA/ALG pairs. By changing the nHA concentration, we can also control the crosslinking degree of the hydrogel network, and further change the mechanical properties, swelling behavior, permeability and diffusivity of the scaffolds. The elastic modulus of the hydrogel scaffolds was regulated from 0.98 +/- 0.05 MPa to 2.78 +/- 0.08 MPa as the concentration of nHA was changed from 50 mg mL(-1) to 300 mg mL(-1), which reached the requirements of avascular soft tissue. The diffusion coefficient was tuned from 23.84 x 10(-7) cm(2) s(-1) to 9.92 x 10(-7) cm(2) s(-1) for controlled mass transport in the hydrogel network. Moreover, human embryo skin fibroblast (ESF) culture experiments prove that nHA can improve cellular adhesion on the hydrogel surface. These results thus suggest that the assembled nHA/ALG hydrogel scaffolds are an attractive biomaterial for great potential application in soft tissue engineering.
DOI10.1039/c0jm02869j
Indexed BySCI
Language英语
WOS IDWOS:000286834600032
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/71676
Collection中国科学院化学研究所
Corresponding AuthorLi, Junbai
Affiliation1.Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, BNLMS,Int Joint Lab, Beijing 100190, Peoples R China
2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Du, Mingchun,Song, Weixing,Cui, Yue,et al. Fabrication and biological application of nano-hydroxyapatite (nHA)/alginate (ALG) hydrogel as scaffolds[J]. JOURNAL OF MATERIALS CHEMISTRY,2011,21(7):2228-2236.
APA Du, Mingchun,Song, Weixing,Cui, Yue,Yang, Yang,&Li, Junbai.(2011).Fabrication and biological application of nano-hydroxyapatite (nHA)/alginate (ALG) hydrogel as scaffolds.JOURNAL OF MATERIALS CHEMISTRY,21(7),2228-2236.
MLA Du, Mingchun,et al."Fabrication and biological application of nano-hydroxyapatite (nHA)/alginate (ALG) hydrogel as scaffolds".JOURNAL OF MATERIALS CHEMISTRY 21.7(2011):2228-2236.
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