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| Quantum dot-antisense oligonucleotide conjugates for multifunctional gene transfection, mRNA regulation, and tracking of biological processes | |
| Li, Yilin; Duan, Xin; Jing, Lihong; Yang, Chunhui; Qiao, Ruirui; Gao, Mingyuan | |
| 2011-03-01 | |
| Source Publication | BIOMATERIALS
 |
| ISSN | 0142-9612 |
| Volume | 32Issue:7Pages:1923-1931 |
| Abstract | It was demonstrated that oligonucleotides, independent of their base sequence and length, could effectively induce the cellular uptake of mercapto acid-capped CdTe QDs after the oligonucleotides were covalently attached on the surface of the QDs. Following these experimental observations, a conjugate composed of covalently linked anti-survivin antisense oligonucleotides (ASON) and CdTe QDs was designed and synthesized. Then, the survivin mRNA down-regulation and the apoptosis of HeLa cells induced by ASON were studied. Systematic experimental results revealed that CdTe-ASON could effectively induce the apoptosis of HeLa cells, while CdTe QDs offered the possibility to visualize the specific intracellular localization of the CdTe-ASON probes strongly associated with their biological functions. (C) 2010 Elsevier Ltd. All rights reserved. |
| Keyword | Cdte Qds Antisense Oligonucleotides Gene Transfection Intracellular Localization Apoptosis |
| DOI | 10.1016/j.biomaterials.2010.11.024 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000287069400018 |
| Publisher | ELSEVIER SCI LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.iccas.ac.cn/handle/121111/71596 |
| Collection | 中国科学院化学研究所 |
| Corresponding Author | Gao, Mingyuan |
| Affiliation | Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Yilin,Duan, Xin,Jing, Lihong,et al. Quantum dot-antisense oligonucleotide conjugates for multifunctional gene transfection, mRNA regulation, and tracking of biological processes[J]. BIOMATERIALS,2011,32(7):1923-1931. |
| APA | Li, Yilin,Duan, Xin,Jing, Lihong,Yang, Chunhui,Qiao, Ruirui,&Gao, Mingyuan.(2011).Quantum dot-antisense oligonucleotide conjugates for multifunctional gene transfection, mRNA regulation, and tracking of biological processes.BIOMATERIALS,32(7),1923-1931. |
| MLA | Li, Yilin,et al."Quantum dot-antisense oligonucleotide conjugates for multifunctional gene transfection, mRNA regulation, and tracking of biological processes".BIOMATERIALS 32.7(2011):1923-1931. |
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