ICCAS OpenIR
Quantum dot-antisense oligonucleotide conjugates for multifunctional gene transfection, mRNA regulation, and tracking of biological processes
Li, Yilin; Duan, Xin; Jing, Lihong; Yang, Chunhui; Qiao, Ruirui; Gao, Mingyuan
2011-03-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume32Issue:7Pages:1923-1931
AbstractIt was demonstrated that oligonucleotides, independent of their base sequence and length, could effectively induce the cellular uptake of mercapto acid-capped CdTe QDs after the oligonucleotides were covalently attached on the surface of the QDs. Following these experimental observations, a conjugate composed of covalently linked anti-survivin antisense oligonucleotides (ASON) and CdTe QDs was designed and synthesized. Then, the survivin mRNA down-regulation and the apoptosis of HeLa cells induced by ASON were studied. Systematic experimental results revealed that CdTe-ASON could effectively induce the apoptosis of HeLa cells, while CdTe QDs offered the possibility to visualize the specific intracellular localization of the CdTe-ASON probes strongly associated with their biological functions. (C) 2010 Elsevier Ltd. All rights reserved.
KeywordCdte Qds Antisense Oligonucleotides Gene Transfection Intracellular Localization Apoptosis
DOI10.1016/j.biomaterials.2010.11.024
Indexed BySCI
Language英语
WOS IDWOS:000287069400018
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/71596
Collection中国科学院化学研究所
Corresponding AuthorGao, Mingyuan
AffiliationChinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li, Yilin,Duan, Xin,Jing, Lihong,et al. Quantum dot-antisense oligonucleotide conjugates for multifunctional gene transfection, mRNA regulation, and tracking of biological processes[J]. BIOMATERIALS,2011,32(7):1923-1931.
APA Li, Yilin,Duan, Xin,Jing, Lihong,Yang, Chunhui,Qiao, Ruirui,&Gao, Mingyuan.(2011).Quantum dot-antisense oligonucleotide conjugates for multifunctional gene transfection, mRNA regulation, and tracking of biological processes.BIOMATERIALS,32(7),1923-1931.
MLA Li, Yilin,et al."Quantum dot-antisense oligonucleotide conjugates for multifunctional gene transfection, mRNA regulation, and tracking of biological processes".BIOMATERIALS 32.7(2011):1923-1931.
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