ICCAS OpenIR
Synthesis of the hemoglobin-conjugated polymer micelles by click chemistry as the oxygen carriers
Li, Tai-hang1,2; Jing, Xia-bin1; Huang, Yu-bin1
2011-08-01
Source PublicationPOLYMERS FOR ADVANCED TECHNOLOGIES
ISSN1042-7147
Volume22Issue:8Pages:1266-1271
AbstractAmphiphilic triblock copolymers were synthesized using MPEG, cyclic carbonic ester monomer including propargyl group (MPC) and L-lactide (LA). These copolymers could self-assemble into core-shell spherical micelles with propargyl groups on the surface. Azided hemoglobin (Hb) was conjugated with the micelles through click reaction to form Hb-bearing nano-micelles. The click reaction conditions, such as the molar ratio of sodium azide to Hb, the binding ratio of Hb to copolymers, the components of catalytic solution, the reaction temperature and time, were thoroughly investigated and optimized. The resulted nano-micelles had 100 nm diameter with 50-60 wt% of Hb content. The Hb-based nano-micelles showed appropriate stability and oxygen carrying capacity, and would have the potential to be used as the new type of artificial oxygen carrier. Copyright (C) 2011 John Wiley & Sons, Ltd.
KeywordArtificial Blood Hemoglobin Click Chemistry Biodegradable Micelles
DOI10.1002/pat.1926
Indexed BySCI
Language英语
WOS IDWOS:000293596700011
PublisherWILEY-BLACKWELL
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/71542
Collection中国科学院化学研究所
Corresponding AuthorHuang, Yu-bin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Tai-hang,Jing, Xia-bin,Huang, Yu-bin. Synthesis of the hemoglobin-conjugated polymer micelles by click chemistry as the oxygen carriers[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2011,22(8):1266-1271.
APA Li, Tai-hang,Jing, Xia-bin,&Huang, Yu-bin.(2011).Synthesis of the hemoglobin-conjugated polymer micelles by click chemistry as the oxygen carriers.POLYMERS FOR ADVANCED TECHNOLOGIES,22(8),1266-1271.
MLA Li, Tai-hang,et al."Synthesis of the hemoglobin-conjugated polymer micelles by click chemistry as the oxygen carriers".POLYMERS FOR ADVANCED TECHNOLOGIES 22.8(2011):1266-1271.
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