ICCAS OpenIR
High-sensitivity biosensors fabricated by tailoring the localized surface plasmon resonance property of core-shell gold nanorods
Huang, Haowen1; Huang, Shaowen1; Yuan, Shishan2; Qu, Caiting1; Chen, Yi3; Xu, Zhongjian1; Liao, Bo1; Zeng, Yunlong1; Chu, Paul K.4
2011-01-10
Source PublicationANALYTICA CHIMICA ACTA
ISSN0003-2670
Volume683Issue:2Pages:242-247
AbstractAn enhanced sensitive biosensor has been developed to detect biological targets by tailoring the localized surface plasmon resonance property of core-shell gold nanorods. In this new concept, a shell layer is produced on gold nanorods by generating a layer of chalcogenide on the gold nanorod surface after attachment of the recognition reagent, namely, goat IgG and antigen of schistosomiasis japonica. The bioactivity of these attached biomolecules is retained and the sensitivity of this biosensor is thus enhanced significantly. The plasmonic properties of the gold nanorods attached with the biomolecules can be adjusted and the plasmon resonance wavelength can be red-shifted up to several hundred nanometers in the visible or near infrared (NIR) region, which is extremely important to biosensing applications. This leads to a lager red-shift in the localized surface plasmon resonance absorption compared to the original gold nanorod-based sensor and hence offers greatly enhanced sensitivity in the detection of schistosomiasis japonica. The human serum infected with schistosomiasis japonica diluted to 1:50,000 (volume ratio, serum/buffer solution) can be detected readily. The technique offers enhanced sensitivity and can be easily extended to other sensing applications based on not only immuno-recognition but also other types of specific reactions. (C) 2010 Elsevier B.V. All rights reserved.
KeywordLocalized Surface Plasmon Resonance Gold Nanorod Composite Schistosomiasis Japonica Biosensor
DOI10.1016/j.aca.2010.10.033
Indexed BySCI
Language英语
WOS IDWOS:000286854700013
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/71494
Collection中国科学院化学研究所
Corresponding AuthorHuang, Haowen
Affiliation1.Hunan Univ Sci & Technol, Key Lab Theoret Chem & Mol Simulat, Minist Educ, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China
2.Hunan Normal Univ, Coll Med, Changsha 410013, Hunan, Peoples R China
3.Chinese Acad Sci, Key Lab Analyt Chem Living Biosyst, Inst Chem, Beijing 100190, Peoples R China
4.City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Huang, Haowen,Huang, Shaowen,Yuan, Shishan,et al. High-sensitivity biosensors fabricated by tailoring the localized surface plasmon resonance property of core-shell gold nanorods[J]. ANALYTICA CHIMICA ACTA,2011,683(2):242-247.
APA Huang, Haowen.,Huang, Shaowen.,Yuan, Shishan.,Qu, Caiting.,Chen, Yi.,...&Chu, Paul K..(2011).High-sensitivity biosensors fabricated by tailoring the localized surface plasmon resonance property of core-shell gold nanorods.ANALYTICA CHIMICA ACTA,683(2),242-247.
MLA Huang, Haowen,et al."High-sensitivity biosensors fabricated by tailoring the localized surface plasmon resonance property of core-shell gold nanorods".ANALYTICA CHIMICA ACTA 683.2(2011):242-247.
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