ICCAS OpenIR
Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate]
Zhang, Rui1; Wang, Yang1; Du, Fu-Sheng1; Wang, Ying-Li2; Tan, Ying-Xia2; Ji, Shou-Ping2; Li, Zi-Chen1
2011-10-10
Source PublicationMACROMOLECULAR BIOSCIENCE
ISSN1616-5187
Volume11Issue:10Pages:1393-1406
AbstractA family of thermoresponsive cationic copolymers (TCPs) that contain branched PEI 25 K as the cationic segment and poly(MEO(2)MA-co-OEGMA(475)) as the thermosensitive block (TP) is prepared. The DNA binding capability, physicochemical properties, and biological performance of the TCPs are studied. All of these TCPs can condense DNA to form polyplexes with diameters of 150-300nm and zeta potentials of 7-32mV at N/P ratios between 12 and 36. The length of TP block is a key factor for shielding the positive surface charge of the polyplexes and protecting them against protein adsorption. TCPs with a higher TP content have a lower cytotoxicity while the best transfection performance is achieved by the TCPs with longest TP length, reaching a level of the intact PEI 25 K in the presence of serum.
KeywordCationic Gene Carriers Hyperthermia Polyethylenimine Poly[Oligo(Ethylene Glycol) Methacrylate] Thermoresponsive
DOI10.1002/mabi.201100094
Indexed BySCI
Language英语
WOS IDWOS:000296138500012
PublisherWILEY-BLACKWELL
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/71466
Collection中国科学院化学研究所
Corresponding AuthorDu, Fu-Sheng
Affiliation1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Polymer Chem & Phys, Minist Educ,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Beijing Inst Transfus Med, Dept Mol Biol, Beijing 100850, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Rui,Wang, Yang,Du, Fu-Sheng,et al. Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate][J]. MACROMOLECULAR BIOSCIENCE,2011,11(10):1393-1406.
APA Zhang, Rui.,Wang, Yang.,Du, Fu-Sheng.,Wang, Ying-Li.,Tan, Ying-Xia.,...&Li, Zi-Chen.(2011).Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate].MACROMOLECULAR BIOSCIENCE,11(10),1393-1406.
MLA Zhang, Rui,et al."Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate]".MACROMOLECULAR BIOSCIENCE 11.10(2011):1393-1406.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Rui]'s Articles
[Wang, Yang]'s Articles
[Du, Fu-Sheng]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Rui]'s Articles
[Wang, Yang]'s Articles
[Du, Fu-Sheng]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Rui]'s Articles
[Wang, Yang]'s Articles
[Du, Fu-Sheng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.