ICCAS OpenIR
Inducement of G-Quadruplex DNA Forming and Down-Regulation of Oncogene C-MYC by Bile Acid-Amino Acid ConjugateBAA
Tian, Mingyue1; Zhang, Xiufeng2; Li, Yan3; Ju, Yong3; Xiang, Junfeng2; Zhao, Changqi1; Tang, Yalin2
2010
Source PublicationNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN1525-7770
Volume29Issue:3Pages:190-199
AbstractHuman c-myc gene is a central regulator of cellular proliferation and cell growth, and G-quadruplexes have been proven to be the transcriptional controller of this gene. In this study, the interaction of bile acid-amino acid conjugate (BAA) with G-quadruplexes in c-myc was investigated by circular dichroism spectroscopy, nuclear magnetic resonance (NMR) measurement, and quantitative real-time polymerase chain reaction (PCR) assay. The experimental results indicated that BAA has the ability to selectively induce the formation of parallel G-quadruplexes in c-myc, which leads to down-regulation of c-myc transcription in the human breast cancer cell MCF-7.
KeywordC-myc Gene G-quadruplexes Bile Acid-amino Acid Conjugate Down-regulation Of Transcription
DOI10.1080/15257771003704875
Indexed BySCI
Language英语
WOS IDWOS:000277621100004
PublisherTAYLOR & FRANCIS INC
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/71186
Collection中国科学院化学研究所
Corresponding AuthorZhao, Changqi
Affiliation1.Beijing Normal Univ, Coll Life Sci, Beijing Key Lab Gene Engn Drugs & Biol Technol, Beijing 100875, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
3.Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Tian, Mingyue,Zhang, Xiufeng,Li, Yan,et al. Inducement of G-Quadruplex DNA Forming and Down-Regulation of Oncogene C-MYC by Bile Acid-Amino Acid ConjugateBAA[J]. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS,2010,29(3):190-199.
APA Tian, Mingyue.,Zhang, Xiufeng.,Li, Yan.,Ju, Yong.,Xiang, Junfeng.,...&Tang, Yalin.(2010).Inducement of G-Quadruplex DNA Forming and Down-Regulation of Oncogene C-MYC by Bile Acid-Amino Acid ConjugateBAA.NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS,29(3),190-199.
MLA Tian, Mingyue,et al."Inducement of G-Quadruplex DNA Forming and Down-Regulation of Oncogene C-MYC by Bile Acid-Amino Acid ConjugateBAA".NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 29.3(2010):190-199.
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