ICCAS OpenIR
Hierarchical gold/copolymer nanostructures as hydrophobic nanotanks for drug encapsulation
Li, Dongxiang1,3; Li, Chunfang1; Wang, Anhe2; He, Qiang3; Li, Junbai2
2010
Source PublicationJOURNAL OF MATERIALS CHEMISTRY
ISSN0959-9428
Volume20Issue:36Pages:7782-7787
AbstractVarious nanoparticles are used to fabricate innovative systems for drug encapsulation and cancer therapy. In this paper, the hierarchical core-shell nanostructures composed of gold nanoparticles and poly(dimethylsiloxane)-poly(ethylene glycol) (PDMS-PEG) block copolymers are fabricated via a hydrosilylation reaction. The obtained gold/copolymer nanocomposites display a desired amphiphilic property and can be well-dispersed in water when the PEG blocks are long enough. The hydrophobic drug hypocrellin B (HB) can be encapsulated into these water-dispersible nanocomposites based on the hydrophobic-hydrophobic interaction between HB molecules and PDMS segments. The gold/copolymer nanocomposites loaded with HB show a rational anticancer ability in the photodynamic therapy although the gold/copolymer nanocomposites without drug also have a little cytotoxicity. Such hierarchically structured core-shell nanocomposites can be considered as water-dispersible nanotanks for hydrophobic drugs in the development of multifunctional biodelivery systems.
DOI10.1039/c0jm01059f
Indexed BySCI
Language英语
WOS IDWOS:000281411000027
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/71044
Collection中国科学院化学研究所
Corresponding AuthorLi, Dongxiang
Affiliation1.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Lab Colloids & Interfaces, State Key Lab Base Ecochem Engn, Qingdao 266042, Peoples R China
2.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid & Interface Sci, Int Joint Lab,BNLMS, Beijing 100080, Peoples R China
3.Max Planck Inst Colloids & Interfaces, Dept Interfaces, D-14476 Golm, Germany
Recommended Citation
GB/T 7714
Li, Dongxiang,Li, Chunfang,Wang, Anhe,et al. Hierarchical gold/copolymer nanostructures as hydrophobic nanotanks for drug encapsulation[J]. JOURNAL OF MATERIALS CHEMISTRY,2010,20(36):7782-7787.
APA Li, Dongxiang,Li, Chunfang,Wang, Anhe,He, Qiang,&Li, Junbai.(2010).Hierarchical gold/copolymer nanostructures as hydrophobic nanotanks for drug encapsulation.JOURNAL OF MATERIALS CHEMISTRY,20(36),7782-7787.
MLA Li, Dongxiang,et al."Hierarchical gold/copolymer nanostructures as hydrophobic nanotanks for drug encapsulation".JOURNAL OF MATERIALS CHEMISTRY 20.36(2010):7782-7787.
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