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| Transition-Metal-Catalyzed Cycloadditions for the Synthesis of Eight-Membered Carbocycles | |
| Yu, Zhi-Xiang; Wang, Yi; Wang, Yuanyuan | |
| 2010 | |
| Source Publication | CHEMISTRY-AN ASIAN JOURNAL
 |
| ISSN | 1861-4728 |
| Volume | 5Issue:5Pages:1072-1088 |
| Abstract | Eight-membered carbocycles are found in a wide variety of natural products that exhibit a broad range of biological and medicinal activities (cf. the most potent anticancer drug, taxol). However, the synthesis of eight-membered carbocycles is quite challenging as traditional approaches are met with entropic and enthalpic penalties in the ring-forming transition states. These negative effects can be totally or partially avoided with the implementation of transition-metal-catalyzed/mediated cycloadditions. In this Focus Review, examples of elegant and efficient metal-catalyzed and some metal-mediated cycloadditions (including Ni- catalyzed [4+4] and Rh-catalyzed [4+2+2] and [5+2+1] reactions) are presented to illustrate this. Application of these cycloaddition reactions in total synthesis is also presented to show the significance of these reactions in addressing challenges in natural product synthesis. |
| Keyword | Cycloaddition Eight-membered Carbocycles Total Synthesis Transition Metals |
| DOI | 10.1002/asia.200900712 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000277724800008 |
| Publisher | WILEY-V C H VERLAG GMBH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.iccas.ac.cn/handle/121111/70982 |
| Collection | 中国科学院化学研究所 |
| Corresponding Author | Yu, Zhi-Xiang |
| Affiliation | Peking Univ, BNLMS, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem, Beijing 100871, Peoples R China |
| Recommended Citation GB/T 7714 | Yu, Zhi-Xiang,Wang, Yi,Wang, Yuanyuan. Transition-Metal-Catalyzed Cycloadditions for the Synthesis of Eight-Membered Carbocycles[J]. CHEMISTRY-AN ASIAN JOURNAL,2010,5(5):1072-1088. |
| APA | Yu, Zhi-Xiang,Wang, Yi,&Wang, Yuanyuan.(2010).Transition-Metal-Catalyzed Cycloadditions for the Synthesis of Eight-Membered Carbocycles.CHEMISTRY-AN ASIAN JOURNAL,5(5),1072-1088. |
| MLA | Yu, Zhi-Xiang,et al."Transition-Metal-Catalyzed Cycloadditions for the Synthesis of Eight-Membered Carbocycles".CHEMISTRY-AN ASIAN JOURNAL 5.5(2010):1072-1088. |
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