ICCAS OpenIR
Towards Characteristics of Photodynamic Drugs Specifically Aimed at Microvascular Diseases
Zhao, Jingquan1; Deng, Hong1; Xie, Jie1; Liu, Xin1; Zhang, Yang1; Huang, Naiyan2; Gu, Ying2
2010-04-01
Source PublicationMINI-REVIEWS IN MEDICINAL CHEMISTRY
ISSN1389-5575
Volume10Issue:4Pages:332-341
AbstractPhotodynamic therapy (PDT) is a versatile methodology to treat various diseases but the drugs (photosensitizers) specifically aimed at individual character of diseases are urgently needed. Among those, the perilenoquinoid photosensitizers were thought of low PDT effectiveness to solid tumors due to low absorption on the "photodynamic window" but may be specially suitable for PDT to some microvascular diseases, such as age-related macular degeneration (AMD) and port wine stains (PWS), as well as other superficial diseases. Two strategies were discussed to convert the photosensitizers into clinically acceptable drugs in consideration of the drug-delivery and biological activity.
KeywordPhotodynamic Therapy (Pdt) Photosensitizers Solid Tumor Microvascular Disease Target-related Characteristic Drug Drug Delivery Biological Activity Drug Preparation
Indexed BySCI
Language英语
WOS IDWOS:000277886300006
PublisherBENTHAM SCIENCE PUBL LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/70974
Collection中国科学院化学研究所
Corresponding AuthorZhao, Jingquan
Affiliation1.Chinese Acad Sci, Inst Chem, Key Lab Photochem, BNLMS, Beijing 100190, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing 100853, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Jingquan,Deng, Hong,Xie, Jie,et al. Towards Characteristics of Photodynamic Drugs Specifically Aimed at Microvascular Diseases[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2010,10(4):332-341.
APA Zhao, Jingquan.,Deng, Hong.,Xie, Jie.,Liu, Xin.,Zhang, Yang.,...&Gu, Ying.(2010).Towards Characteristics of Photodynamic Drugs Specifically Aimed at Microvascular Diseases.MINI-REVIEWS IN MEDICINAL CHEMISTRY,10(4),332-341.
MLA Zhao, Jingquan,et al."Towards Characteristics of Photodynamic Drugs Specifically Aimed at Microvascular Diseases".MINI-REVIEWS IN MEDICINAL CHEMISTRY 10.4(2010):332-341.
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