Lactose mediated liver-targeting effect observed by ex vivo imaging technology
Ma, Ping'an2; Liu, Shi1; Huang, Yubin1; Chen, Xuesi1; Zhang, Liping2; Jing, Xiabin1
Source PublicationBIOMATERIALS
AbstractTwo kinds of micelles containing Rhodamine B were prepared by a solvent evaporation method One (Lac-f-micelles lactose-free micelles) was from a Rhodamine-containing copolymer, poly(ethylene glycol)-b-poly(L-lactide-co-2,2-dihydroxylmethyl-propylene carbonate/Rhodamine) [PEC(5000)-b-P(LA(4000)-co-DHP(600)/Rhodamine)], and the other (Lac | micelles lactose-containing micelles) was from a mixture of the targeting copolymer lactose-poly(ethylene glycol)-poly (L-Lactide) [Lac-PEG(4600)-PLA(4500)] and the Rhodamine-containing copolymer PEG(5000)-b-P(LA(4000)-co-DHP(600)/Rhodamine) ESEM and DLS measurements showed that the two kinds of micelles have similar size (in the range of 60-100 nm) and size distribution Cellular uptake Studies in vitro revealed that the Lac+micelles showed stronger endocytosis ability than Lac-f-micelles in SMMC7221 human liver cancer cells, but the Lac+micelles were rarely internalized by Vero cells The micelle solutions were administrated into mice via tail intravenous injection. Then, five visceral organs were isolated from the mice at specified time intervals and relative fluorescent intensities of the ex vivo organs and their homogenates were examined by CRI Maestro 500FL in vivo imaging system The results showed that the Lac+micelles showed more remarkable liver-targeting effect than the Lac-f-micelles And the liver-targeting effect Could be established in ca 12 h after tail i v injection (C) 2009 Elsevier Ltd All rights reserved
KeywordEx Vivo Imaging Lactose Liver-targeting Mixed Micelles Rhodamine b
Indexed BySCI
WOS IDWOS:000275348800022
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Cited Times:71[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorJing, Xiabin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.NE Normal Univ, Sch Life Sci, Changchun 130024, Peoples R China
Recommended Citation
GB/T 7714
Ma, Ping'an,Liu, Shi,Huang, Yubin,et al. Lactose mediated liver-targeting effect observed by ex vivo imaging technology[J]. BIOMATERIALS,2010,31(9):2646-2654.
APA Ma, Ping'an,Liu, Shi,Huang, Yubin,Chen, Xuesi,Zhang, Liping,&Jing, Xiabin.(2010).Lactose mediated liver-targeting effect observed by ex vivo imaging technology.BIOMATERIALS,31(9),2646-2654.
MLA Ma, Ping'an,et al."Lactose mediated liver-targeting effect observed by ex vivo imaging technology".BIOMATERIALS 31.9(2010):2646-2654.
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