ICCAS OpenIR
Cytotoxicity of Zinc Oxide Nanoparticles: Importance of Microenvironment
Yang, Sheng-Tao1; Liu, Jia-Hui1; Wang, Jing1; Yuan, Yuan1; Cao, Aoneng2; Wang, Haifang1,2; Liu, Yuanfang1,2; Zhao, Yuliang3,4
2010-12-01
Source PublicationJOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN1533-4880
Volume10Issue:12Pages:8638-8645
AbstractWhile ZnO particles are widely used in many fields, including personal care products, the high toxicity of ZnO nanoparticles has been reported and aroused great health concerns. In this study, the cytotoxicity of ZnO nanoparticles was evaluated and, in particular, the role of microenvironment in their toxicity was investigated. Our results show that ZnO nanoparticles are highly toxic to NIH/3T3 cells, inducing viability loss, membrane leakage and morphology changes. The microenviroment, here the CO(2) atmosphere under cell culture condition, promoted the solubilization of ZnO nanoparticles. Then the released Zn from ZnO nanoparticles induces the cytotoxicity. The importance of microenvironment on the ZnO nanotoxicity is presented and the implications to future nanotoxicology studies are discussed.
KeywordZinc Oxide Nanoparticles Cytotoxicity Solubility Microenvironment
DOI10.1166/jnn.2010.2491
Indexed BySCI ; ISTP
Language英语
WOS IDWOS:000283621400104
PublisherAMER SCIENTIFIC PUBLISHERS
Citation statistics
Cited Times:52[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/70718
Collection中国科学院化学研究所
Corresponding AuthorWang, Haifang
Affiliation1.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
3.Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
4.Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Yang, Sheng-Tao,Liu, Jia-Hui,Wang, Jing,et al. Cytotoxicity of Zinc Oxide Nanoparticles: Importance of Microenvironment[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(12):8638-8645.
APA Yang, Sheng-Tao.,Liu, Jia-Hui.,Wang, Jing.,Yuan, Yuan.,Cao, Aoneng.,...&Zhao, Yuliang.(2010).Cytotoxicity of Zinc Oxide Nanoparticles: Importance of Microenvironment.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(12),8638-8645.
MLA Yang, Sheng-Tao,et al."Cytotoxicity of Zinc Oxide Nanoparticles: Importance of Microenvironment".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.12(2010):8638-8645.
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