ICCAS OpenIR
Local site preference rationalizes disentangling by DNA topoisomerases
Liu, Zhirong1,2; Zechiedrich, Lynn3,4; Chan, Hue Sun5,6,7
2010-03-01
Source PublicationPHYSICAL REVIEW E
ISSN1539-3755
Volume81Issue:3
AbstractTo rationalize the disentangling action of type II topoisomerases, an improved wormlike DNA model was used to delineate the degree of unknotting and decatenating achievable by selective segment passage at specific juxtaposition geometries and to determine how these activities were affected by DNA circle size and solution ionic strength. We found that segment passage at hooked geometries can reduce knot populations as dramatically as seen in experiments. Selective segment passage also provided theoretical underpinning for an intriguing empirical scaling relation between unknotting and decatenating potentials.
DOI10.1103/PhysRevE.81.031902
Indexed BySCI
Language英语
WOS IDWOS:000276199300085
PublisherAMER PHYSICAL SOC
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/70678
Collection中国科学院化学研究所
Corresponding AuthorLiu, Zhirong
Affiliation1.Peking Univ, Coll Chem & Mol Engn, Ctr Theoret Biol, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China
2.Peking Univ, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
3.Baylor Coll Med, Verna & Marrs McLean Dept Biochem & Mol Biol, Dept Mol Virol & Microbiol, Houston, TX 77030 USA
4.Baylor Coll Med, Dept Pharmacol, Houston, TX 77030 USA
5.Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada
6.Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada
7.Univ Toronto, Dept Phys, Toronto, ON M5S 1A7, Canada
Recommended Citation
GB/T 7714
Liu, Zhirong,Zechiedrich, Lynn,Chan, Hue Sun. Local site preference rationalizes disentangling by DNA topoisomerases[J]. PHYSICAL REVIEW E,2010,81(3).
APA Liu, Zhirong,Zechiedrich, Lynn,&Chan, Hue Sun.(2010).Local site preference rationalizes disentangling by DNA topoisomerases.PHYSICAL REVIEW E,81(3).
MLA Liu, Zhirong,et al."Local site preference rationalizes disentangling by DNA topoisomerases".PHYSICAL REVIEW E 81.3(2010).
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