New Progress in Noninvasive Method of Blood Glucose Measurement Using FT-Mid-IR Spectroscopy
Wang Man-man1,2; Bai Qian1,3; Pan Qing-hua1,4; Zhang Yuan-fu1; Weng Shi-fu1; Zhou Feng-shan2; Gong Rong-ye5; Wu Hui-zhong5; Xu Yi-zhuang1; Wu Jin-guang1
AbstractThe blood glucose concentrations of volunteers from diabetes patients and healthy adults (all patients and volunteers who joined this experiment gave their consents) were measured by using a modified WQF-200 FTIR spectrometer with a newly designed ATR accessory from the Beijing Rayleigh Analytical Instrument Corp. The determination basis for this technique from the physiological point of view is also discussed based on the experimental results, which indicated that the glucose measured by the FT-Mid-IR-ATR instrument is from the secretions on the skin and glucose components within the body. The secreted glucose components will increase with the time increasing. The authors' previous study([3-8]) demonstrated 1 120 cm(-1) band as an index to characterize the blood glucose. During the experiments, the authors used the band of 1 455 cm(-1) as internal standard because of its stability, and because the relative intensity of I(1) (120)/I(1) (455) band possesses the higher sensitivity. Meanwhile, from the spectra, the relative intensity of I(1 120)/I(1 455) band of the glucose in both sources exhibits a linear relationship with blood glucose concentration within the body. The dried blood has the similar spectra as fingers'. The fingers' spectra will exhibit higher sensitivity if the time of measurement is longer after washing hand, and the results showed that when measured 10 minutes after washing hand, the sensitivity will be higher than that when measured 4 minutes after washing hand. All the results can be used in promoting a convenient, rapid and noninvasive way to monitor the continuous variation of blood glucose concentration of diabetes patients in real time.
KeywordFt-mid-ir Spectroscopy Non-invasive Method Blood Glucose Diabetes
Indexed BySCI
WOS IDWOS:000278580200008
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorXu Yi-zhuang
Affiliation1.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.China Univ Geosci, Sch Mat Sci & Technol, Beijing 100083, Peoples R China
3.Univ Saskatchewan, Saskatoon, SK S7N 5C9, Canada
4.Hangzhou Normal Univ, Lab Organosilicon Chem & Mat Technol, Hangzhou 310015, Zhejiang, Peoples R China
5.Beijing Rayleigh Analyt Instrument Corp, Beijing 100016, Peoples R China
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GB/T 7714
Wang Man-man,Bai Qian,Pan Qing-hua,et al. New Progress in Noninvasive Method of Blood Glucose Measurement Using FT-Mid-IR Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2010,30(6):1474-1477.
APA Wang Man-man.,Bai Qian.,Pan Qing-hua.,Zhang Yuan-fu.,Weng Shi-fu.,...&Wu Jin-guang.(2010).New Progress in Noninvasive Method of Blood Glucose Measurement Using FT-Mid-IR Spectroscopy.SPECTROSCOPY AND SPECTRAL ANALYSIS,30(6),1474-1477.
MLA Wang Man-man,et al."New Progress in Noninvasive Method of Blood Glucose Measurement Using FT-Mid-IR Spectroscopy".SPECTROSCOPY AND SPECTRAL ANALYSIS 30.6(2010):1474-1477.
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