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SYNTHESIS OF TERPYRIDINE-FUNCTIONALIZED POLY (N-ISOPROPYLACYLAMIDE) S AND THEIR METAL COMPLEXES
Sun Peijian1,2; Shi Xudong1; Gan Zhihua1
2010-04-20
Source PublicationACTA POLYMERICA SINICA
ISSN1000-3304
Issue4Pages:383-389
AbstractA new terpyridine-functionalized dithioester was synthesized as a chain transfer agent in the reversible addition fragmentation chain transfer polymerization (RAFT) of N-isopropylacyamide (NIPAAm). The polymerization showed an first-order kinetics and the molecular weight increased linearly with conversion, indicating that the terpyridine-functionalized dithioester is an efficient chain transfer agent for the RAFT polymerization of NIPAAm. The terpyridine-functionalized poly (N-isopropylacyamide) (tpy-PNIPAAm) not only displays similar phase transition as PNIPAAm, but also have the coordination ability via terpyridine, which were further used to construct macromolecular-metal complex with ferrous ions as model metal ions. The appearance of a strong absorption at 555 nm in UV-Vis spectrum revealed the formation of macromolecular-metal complex, indicating the strong coordination ability of tpy-PNIPAAm to metal. Cloud point method and dynamic light scattering (DLS) were used to characterize the thermosensitivity of tpy-PNIPAAm and macromolecular-metal complex. The results showed that the macromolecular-metal complex could self-assemble into nanoparticles in aqueous solution due to the amphiphilic property The macromolecular-metal complex solution showed a similar phase transition as PNIPAAm. In addition, the nanoparticles of the macromolecular-metal complex in aqueous solution were stable even at temperature above the lower critical solution temperature (LCST) due to electrostatic repulsion. This work indicated the great potentials of tpy-PNIPAAm as carriers for the delivery of therapeutic radioisotopes.
KeywordRaft Poly(N-isopropylacyamide) Terpyridine Thermo-sensitive Therapeutic Isotopes
Indexed BySCI
Language英语
WOS IDWOS:000277591700001
PublisherSCIENCE CHINA PRESS
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/70582
Collection中国科学院化学研究所
Corresponding AuthorSun Peijian
Affiliation1.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Sun Peijian,Shi Xudong,Gan Zhihua. SYNTHESIS OF TERPYRIDINE-FUNCTIONALIZED POLY (N-ISOPROPYLACYLAMIDE) S AND THEIR METAL COMPLEXES[J]. ACTA POLYMERICA SINICA,2010(4):383-389.
APA Sun Peijian,Shi Xudong,&Gan Zhihua.(2010).SYNTHESIS OF TERPYRIDINE-FUNCTIONALIZED POLY (N-ISOPROPYLACYLAMIDE) S AND THEIR METAL COMPLEXES.ACTA POLYMERICA SINICA(4),383-389.
MLA Sun Peijian,et al."SYNTHESIS OF TERPYRIDINE-FUNCTIONALIZED POLY (N-ISOPROPYLACYLAMIDE) S AND THEIR METAL COMPLEXES".ACTA POLYMERICA SINICA .4(2010):383-389.
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