ICCAS OpenIR
Chiral Amine Thiourea-Promoted Enantioselective Michael Addition Reactions of 3-Substituted Benzofuran-2(3H)-ones to Maleimides
Li, Xin1,2; Hu, Shenshen3; Xi, Zhiguo1,2; Zhang, Long3; Luo, Sanzhong3; Cheng, Jin-Pei1,2
2010-12-17
Source PublicationJOURNAL OF ORGANIC CHEMISTRY
ISSN0022-3263
Volume75Issue:24Pages:8697-8700
AbstractA highly diastereo- and enantioselective Michael addition reaction with respect to prochiral 3-substituted benzofuran-2(3H)-ones and maleimides by a chiral bifunctional thiourea-tertiary amine catalyst was investigated. The corresponding adducts, containing a quaternary center at the C3-position of the benzofuran-2(3H)-one as well as a vicinal tertiary center, were generally obtained in high yields (up to 99%) with very good diastereo- (up to > 20:1 dr) and enantioselectivities (up to 97% cc).
DOI10.1021/j0101832e
Indexed BySCI ; IC
Language英语
WOS IDWOS:000285081100048
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:57[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/70552
Collection中国科学院化学研究所
Corresponding AuthorLi, Xin
Affiliation1.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
2.Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li, Xin,Hu, Shenshen,Xi, Zhiguo,et al. Chiral Amine Thiourea-Promoted Enantioselective Michael Addition Reactions of 3-Substituted Benzofuran-2(3H)-ones to Maleimides[J]. JOURNAL OF ORGANIC CHEMISTRY,2010,75(24):8697-8700.
APA Li, Xin,Hu, Shenshen,Xi, Zhiguo,Zhang, Long,Luo, Sanzhong,&Cheng, Jin-Pei.(2010).Chiral Amine Thiourea-Promoted Enantioselective Michael Addition Reactions of 3-Substituted Benzofuran-2(3H)-ones to Maleimides.JOURNAL OF ORGANIC CHEMISTRY,75(24),8697-8700.
MLA Li, Xin,et al."Chiral Amine Thiourea-Promoted Enantioselective Michael Addition Reactions of 3-Substituted Benzofuran-2(3H)-ones to Maleimides".JOURNAL OF ORGANIC CHEMISTRY 75.24(2010):8697-8700.
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