ICCAS OpenIR
Photoresponsive Nanocarriers Based on PAMAM Dendrimers with a o-Nitrobenzyl Shell
Li, Yan1; Jia, Xinru1; Gao, Min1; He, Hai1; Kuang, Guichao1; Wei, Yen2
2010-02-01
Source PublicationJOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
ISSN0887-624X
Volume48Issue:3Pages:551-557
AbstractGn (n = 3, 4, and 5) poly(amidoamine) (PAMAM) dendrimers were synthesized and peripherally modified with photocleavable o-nitrobenzyl (NB) groups by reacting o-nitrobenzaldehyde with the terminal amine groups of PAMAM dendrimers, followed by reducing the imine to amine groups with NaBH(4). The NB-modified dendrimers, Gn-NB (n = 3, 4, and 5), were characterized by nuclear magnetic resonance and fourier transform infrared spectroscopy. The results showed that the NB groups were successfully attached on the periphery of the dendrimers with near 100% grafting efficiency. Such a photosensitive NB shell could be cut off on irradiation with 365 nm ultraviolet (UV) light. The encapsulation and release of guest molecules, that is, salicylic acid (SA) and adriamycin (ADR), by Gn-NB were explored. The encapsulation capability of these dendrimers was found to increase as the guest molecular size was decreased and have dependence on the generation of dendrimers as well. For both of SA and ADR, the average encapsulation numbers per dendrimer decreased in the order of G4-NB > G5-NB > G3-NB, indicating that the fourth generation dendrimer was a better container for the guest molecules. The rate of SA release was found to be greater with UV irradiation than that without, suggesting that the NB-shelled PAMMAM dendrimers could function as a molecular container/box with photoresponsive characteristics. (C) 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 551-557, 2010
KeywordDrug Delivery Systems Pamam Dendrimers O-nitrobenzyl Photochemistry
DOI10.1002/pola.23757
Indexed BySCI
Language英语
WOS IDWOS:000274254600006
PublisherJOHN WILEY & SONS INC
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/70476
Collection中国科学院化学研究所
Corresponding AuthorJia, Xinru
Affiliation1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Polymer Chem & Phys, Minist Educ,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Drexel Univ, Dept Chem, Philadelphia, PA 19104 USA
Recommended Citation
GB/T 7714
Li, Yan,Jia, Xinru,Gao, Min,et al. Photoresponsive Nanocarriers Based on PAMAM Dendrimers with a o-Nitrobenzyl Shell[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2010,48(3):551-557.
APA Li, Yan,Jia, Xinru,Gao, Min,He, Hai,Kuang, Guichao,&Wei, Yen.(2010).Photoresponsive Nanocarriers Based on PAMAM Dendrimers with a o-Nitrobenzyl Shell.JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,48(3),551-557.
MLA Li, Yan,et al."Photoresponsive Nanocarriers Based on PAMAM Dendrimers with a o-Nitrobenzyl Shell".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 48.3(2010):551-557.
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