ICCAS OpenIR
Conjugated polymers as multifunctional biomedical platforms: Anticancer activity and apoptosis imaging
Liu, Libing; Yu, Minghui; Duan, Xinrui; Wang, Shu
2010
Source PublicationJOURNAL OF MATERIALS CHEMISTRY
ISSN0959-9428
Volume20Issue:33Pages:6942-6947
AbstractRecent advances in biological applications of conjugated polymers have focused on highly sensitive diagnostics. The therapeutics of conjugated polymers, however, remains a challenging task. Here we explore for the first time that cationic polythiophene (PMNT) is used as a multifunctional agent for simultaneous cancer therapeutic and apoptosis imaging applications. The anticancer mechanism study showed that the PMNT can uptake inside renal cell carcinoma (A498) cancer cells in a diffusion manner and induce their apoptosis. The increased activation of caspase-3 have been shown to be time- and dose-dependent on PMNT, which indicates a signaling transduction pathway of PMNT induced-apoptosis in A498 cells. Beyond conventional endpoint analysis of apoptosis using multiplex dyes, the PMNT can image the cells and clearly distinguish the living and apoptotic cancer cells. Strikingly, the PMNT could quickly induce cell apoptosis within several minutes under irradiation. The PMNT integrates photosensitivity, anticancer activity and apoptosis imaging, which opens the door for new functional studies of conjugated polymers in disease therapeutics.
DOI10.1039/c0jm01078b
Indexed BySCI
Language英语
WOS IDWOS:000280818000016
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:40[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/70424
Collection中国科学院化学研究所
Corresponding AuthorLiu, Libing
AffiliationChinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Liu, Libing,Yu, Minghui,Duan, Xinrui,et al. Conjugated polymers as multifunctional biomedical platforms: Anticancer activity and apoptosis imaging[J]. JOURNAL OF MATERIALS CHEMISTRY,2010,20(33):6942-6947.
APA Liu, Libing,Yu, Minghui,Duan, Xinrui,&Wang, Shu.(2010).Conjugated polymers as multifunctional biomedical platforms: Anticancer activity and apoptosis imaging.JOURNAL OF MATERIALS CHEMISTRY,20(33),6942-6947.
MLA Liu, Libing,et al."Conjugated polymers as multifunctional biomedical platforms: Anticancer activity and apoptosis imaging".JOURNAL OF MATERIALS CHEMISTRY 20.33(2010):6942-6947.
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