ICCAS OpenIR
Structure and properties of polysaccharide nanocrystal-doped supramolecular hydrogels based on Cyclodextrin inclusion
Zhang, Xiaolan1; Huang, Jin1,4,5; Chang, Peter R.2; Li, Junli1; Chen, Yongming7; Wang, Daxin3; Yu, Jiahui4; Chen, Jinghua6
2010-09-03
Source PublicationPOLYMER
ISSN0032-3861
Volume51Issue:19Pages:4398-4407
AbstractPolysaccharide nanocrystals, such as the rod-like whiskers of cellulose and chitin, and platelet-like starch nanocrystals, were for the first time incorporated into supramolecular hydrogels based on cyclodextrin/polymer inclusion in order to enhance mechanical strength and regulate drug release behavior The structures and properties of the resultant nanocomposite hydrogels were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and rheological testing As expected, the elastic modulus of the nanocomposite hydrogels climbed, owing to the reinforcing function of the polysaccharide nanocrystals The modulus of the cellulose whisker-doped hydrogel was 50 times higher than that of the native hydrogel Furthermore, the presence of polysaccharide nanocrystals increased the stability of the hydrogel framework and inhibited the diffusion of bovine serum albumin, which served as a model protein drug in the nanocomposite hydrogels and showed prominent sustained release profiles Importantly, the incorporation of polysaccharide nanocrystals did not show additional cytotoxicity as comparison with the native hydrogel In addition, the inherited shear-thinning property of the nanocomposite hydrogels contributed to their potential as injectable biomaterials (C) 2010 Elsevier Ltd All rights reserved.
KeywordSupramolecular Hydrogel Cyclodextrin Inclusion Polysaccharide Nanocrystal
DOI10.1016/j.polymer.2010.07.025
Indexed BySCI
Language英语
WOS IDWOS:000281506100015
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:85[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/70372
Collection中国科学院化学研究所
Corresponding AuthorHuang, Jin
Affiliation1.Wuhan Univ Technol, Coll Chem Engn, Wuhan 430070, Peoples R China
2.Agr & Agri Food Canada, Bioprod & Bioproc Natl Sci Program, Saskatoon, SK S7N 0X2, Canada
3.Yangzhou Univ, Subei Peoples Hosp Jiangsu Prov, Yangzhou 225001, Peoples R China
4.E China Normal Univ, Interdisciplinary Sci & Technol Inst Adv Study, Shanghai 200062, Peoples R China
5.S China Univ Technol, State Key Lab Pulp & Paper Engn, Guangzhou 510640, Guangdong, Peoples R China
6.Jiangnan Univ, Sch Med & Pharmaceut, Wuxi 214122, Peoples R China
7.Chinese Acad Sci, Inst Chem, Div Polymer Sci & Mat, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xiaolan,Huang, Jin,Chang, Peter R.,et al. Structure and properties of polysaccharide nanocrystal-doped supramolecular hydrogels based on Cyclodextrin inclusion[J]. POLYMER,2010,51(19):4398-4407.
APA Zhang, Xiaolan.,Huang, Jin.,Chang, Peter R..,Li, Junli.,Chen, Yongming.,...&Chen, Jinghua.(2010).Structure and properties of polysaccharide nanocrystal-doped supramolecular hydrogels based on Cyclodextrin inclusion.POLYMER,51(19),4398-4407.
MLA Zhang, Xiaolan,et al."Structure and properties of polysaccharide nanocrystal-doped supramolecular hydrogels based on Cyclodextrin inclusion".POLYMER 51.19(2010):4398-4407.
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