ICCAS OpenIR
Investigation of Interaction of Small Natural Product Molecules and Human Telomeric G-Quadruplex and Thermal Stabilities of the Complexes by Electrospray Ionization Mass Spectrometry
He Xiang-Wei1; Long Hai-Tao1; Yuan Gu1; Xu Xiao-Jie; Zhou Ya-Wei2
2010-04-01
Source PublicationACTA PHYSICO-CHIMICA SINICA
ISSN1000-6818
Volume26Issue:4Pages:1082-1086
AbstractElectrospray ionization mass spectrometry (ESI-MS) was used to investigate the non-covalent interaction of human telomenc G-quadruplex (G4) DNA with 12 natural product molecules We found that Fangchinoline, a new ligand of the human telomenc G-quadruplex, had the highest binding affinity among these molecules The stabilities of the G-quadruplex and the complexes of the G-quadruplex with small molecules were investigated using a mass spectrometry heating experiment By Fangchinoline binding, the dissociation temperature (T-1/2) value of the complex of G-quadruplex with the ligand increased to 200 degrees C. We studied the binding mode and stability of the G-quadruplex with the small molecules using Autodock Possible binding sites were found and the binding energy was about -31 5 kJ mol Unlike the typical binding molecules with a planar structure. Fangchinoline is a new kind of G-quadruplex ligand and it gives us a different Insight for the design of new G-quadruplex ligands
KeywordMolecular Modeling Telomere G-quadruplex Dna Natural Product Molecule Electrospray Ionization Mass Spectrometry
DOI10.3866/PKU.WHXB20100416
Indexed BySCI
Language英语
WOS IDWOS:000276958400036
PublisherPEKING UNIV PRESS
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/70298
Collection中国科学院化学研究所
Corresponding AuthorYuan Gu
Affiliation1.Peking Univ, Coll Chem & Mol Engn, Key Lab Bioorgan & Mol Engn, Beijing Natl Lab Mol Sci,Educ Minist,Dept Chem Bi, Beijing 100871, Peoples R China
2.Peking Univ, Baschoior Res Ctr, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
He Xiang-Wei,Long Hai-Tao,Yuan Gu,et al. Investigation of Interaction of Small Natural Product Molecules and Human Telomeric G-Quadruplex and Thermal Stabilities of the Complexes by Electrospray Ionization Mass Spectrometry[J]. ACTA PHYSICO-CHIMICA SINICA,2010,26(4):1082-1086.
APA He Xiang-Wei,Long Hai-Tao,Yuan Gu,Xu Xiao-Jie,&Zhou Ya-Wei.(2010).Investigation of Interaction of Small Natural Product Molecules and Human Telomeric G-Quadruplex and Thermal Stabilities of the Complexes by Electrospray Ionization Mass Spectrometry.ACTA PHYSICO-CHIMICA SINICA,26(4),1082-1086.
MLA He Xiang-Wei,et al."Investigation of Interaction of Small Natural Product Molecules and Human Telomeric G-Quadruplex and Thermal Stabilities of the Complexes by Electrospray Ionization Mass Spectrometry".ACTA PHYSICO-CHIMICA SINICA 26.4(2010):1082-1086.
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