ICCAS OpenIR
Biotransformations of Three-Membered (Hetero) Cyclic Nitrites and Their Applications in Organic Synthesis
Wang Dexian1; Wang Meixiang1,2
2010-07-01
Source PublicationPROGRESS IN CHEMISTRY
ISSN1005-281X
Volume22Issue:7Pages:1397-1402
AbstractEnantioselective biotransformation of nitriles using nitrile hydrolyzing microbial whole cell catalysts is a powerful method for the synthesis of highly enantiopure carboxylic acids and amide derivatives. In this article, progress of Rhodococcus erythropolis AJ270-catalyzed enantioselective biotransformations of nitriles including various cyclopropane-, oxirane-, and aziridine-containing carbonitriles is summarized. On the basis of the outcomes of the biotransformation study, it is proposed that a readily reachable reactive site be embedded within the spacious pocket of the nitrile hydratase while the amidase might comprise a relatively deep-buried and size-limited active site. Applications of enantioselective biotransformations of nitriles in the synthesis of natural and bioactive products are also discussed.
KeywordRhodococcus Erythropolis Aj270 Biocatalysis And Biotransformation Enantioselectivity Nitrites Amides
Indexed BySCI
Language英语
WOS IDWOS:000280274000012
PublisherCHINESE ACAD SCIENCES
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/70192
Collection中国科学院化学研究所
Corresponding AuthorWang Meixiang
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
2.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Wang Dexian,Wang Meixiang. Biotransformations of Three-Membered (Hetero) Cyclic Nitrites and Their Applications in Organic Synthesis[J]. PROGRESS IN CHEMISTRY,2010,22(7):1397-1402.
APA Wang Dexian,&Wang Meixiang.(2010).Biotransformations of Three-Membered (Hetero) Cyclic Nitrites and Their Applications in Organic Synthesis.PROGRESS IN CHEMISTRY,22(7),1397-1402.
MLA Wang Dexian,et al."Biotransformations of Three-Membered (Hetero) Cyclic Nitrites and Their Applications in Organic Synthesis".PROGRESS IN CHEMISTRY 22.7(2010):1397-1402.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang Dexian]'s Articles
[Wang Meixiang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang Dexian]'s Articles
[Wang Meixiang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang Dexian]'s Articles
[Wang Meixiang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.