ICCAS OpenIR
A multitechnique study of europium decatungstate and human serum albumin molecular interaction
Zheng, Li2,4; Ma, Ying2; Zhang, Guangjin1; Yao, Jiannian2; Keita, Bineta3; Nadjo, Louis3
2010
Source PublicationPHYSICAL CHEMISTRY CHEMICAL PHYSICS
ISSN1463-9076
Volume12Issue:6Pages:1299-1304
AbstractPolyoxometalates (POMs) show promising biological activities, but the mechanism of these potential therapeutic effects remains to be elucidated at a molecular level. As a step in this direction, the interaction between the Eu-containing decatungstate [EuW(10)O(36)](9-) and human serum albumin (HSA) has been studied by several techniques. Fluorescence/luminescence analysis showed the existence of a strong interaction between the POM and HSA. This interaction has key effects both on luminescence of the POM and on the behaviours of HSA. An enhancement of the POM luminescence is observed upon interaction. The presence of increasing concentrations of the POM results in the progressive quenching of the fluorescence of the single tryptophan of HSA. Circular dichroism led to the conclusion that the binding of the POM did not alter the secondary structure of HSA. Isothermal titration calorimetry revealed an enthalpy-driven binding reaction between HSA and the POM, resulting in the formation of a 1 : 1 complex. The present work is meaningful in finding novel solid state bio-image or fluorescence/luminescence labelling agents.
DOI10.1039/b919952g
Indexed BySCI
Language英语
WOS IDWOS:000274072900009
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:49[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/70152
Collection中国科学院化学研究所
Corresponding AuthorZhang, Guangjin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Photochem, Inst Chem, Beijing 100190, Peoples R China
3.Univ Paris 11, CNRS, UMR 8000, Chim Phys Lab, F-91405 Orsay, France
4.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Li,Ma, Ying,Zhang, Guangjin,et al. A multitechnique study of europium decatungstate and human serum albumin molecular interaction[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2010,12(6):1299-1304.
APA Zheng, Li,Ma, Ying,Zhang, Guangjin,Yao, Jiannian,Keita, Bineta,&Nadjo, Louis.(2010).A multitechnique study of europium decatungstate and human serum albumin molecular interaction.PHYSICAL CHEMISTRY CHEMICAL PHYSICS,12(6),1299-1304.
MLA Zheng, Li,et al."A multitechnique study of europium decatungstate and human serum albumin molecular interaction".PHYSICAL CHEMISTRY CHEMICAL PHYSICS 12.6(2010):1299-1304.
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