Intrinsically Disordered Proteins: the New Sequence-Structure-Function Relations
Huang Yong-Qi; Liu Zhi-Rong
AbstractIntrinsically disordered proteins (IDPs) are a new class of proteins which lack a unique tertiary structure under native conditions while possessing essential biological functions. They take part in various physiological processes such as signal transduction, transcription and translation regulation, and protein modification. The discovery of IDPs challenges the conventional protein "sequence-structure-function" paradigm. In this review, we first overview the history of the conventional protein paradigm and the discovery of IDPs. Then we discuss the characteristics of IDPs in terms of sequence, structure, and biological function. Taking molecular recognition processes as an example, we further introduce current opinions on the advantages of IDPs in binding. Finally, we analyze possible applications of the study of IDPs such as further understanding the protein folding mechanism, improving protein structure determination, providing new clues for protein design and new targets for drug design. The current status of IDPs study in China is also briefly presented.
KeywordIntrinsically Disordered Protein Protein Folding Protein Interaction Molecular Recognition Protein Structure Prediction Drug Design
Indexed BySCI
WOS IDWOS:000280259900002
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Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorLiu Zhi-Rong
AffiliationPeking Univ, Coll Chem & Mol Engn, Ctr Theoret Biol, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
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GB/T 7714
Huang Yong-Qi,Liu Zhi-Rong. Intrinsically Disordered Proteins: the New Sequence-Structure-Function Relations[J]. ACTA PHYSICO-CHIMICA SINICA,2010,26(8):2061-2072.
APA Huang Yong-Qi,&Liu Zhi-Rong.(2010).Intrinsically Disordered Proteins: the New Sequence-Structure-Function Relations.ACTA PHYSICO-CHIMICA SINICA,26(8),2061-2072.
MLA Huang Yong-Qi,et al."Intrinsically Disordered Proteins: the New Sequence-Structure-Function Relations".ACTA PHYSICO-CHIMICA SINICA 26.8(2010):2061-2072.
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