ICCAS OpenIR
Intrinsically Disordered Proteins: the New Sequence-Structure-Function Relations
Huang Yong-Qi; Liu Zhi-Rong
2010-08-01
Source PublicationACTA PHYSICO-CHIMICA SINICA
ISSN1000-6818
Volume26Issue:8Pages:2061-2072
AbstractIntrinsically disordered proteins (IDPs) are a new class of proteins which lack a unique tertiary structure under native conditions while possessing essential biological functions. They take part in various physiological processes such as signal transduction, transcription and translation regulation, and protein modification. The discovery of IDPs challenges the conventional protein "sequence-structure-function" paradigm. In this review, we first overview the history of the conventional protein paradigm and the discovery of IDPs. Then we discuss the characteristics of IDPs in terms of sequence, structure, and biological function. Taking molecular recognition processes as an example, we further introduce current opinions on the advantages of IDPs in binding. Finally, we analyze possible applications of the study of IDPs such as further understanding the protein folding mechanism, improving protein structure determination, providing new clues for protein design and new targets for drug design. The current status of IDPs study in China is also briefly presented.
KeywordIntrinsically Disordered Protein Protein Folding Protein Interaction Molecular Recognition Protein Structure Prediction Drug Design
DOI10.3866/PKU.WHXB20100644
Indexed BySCI
Language英语
WOS IDWOS:000280259900002
PublisherPEKING UNIV PRESS
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/69932
Collection中国科学院化学研究所
Corresponding AuthorLiu Zhi-Rong
AffiliationPeking Univ, Coll Chem & Mol Engn, Ctr Theoret Biol, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Huang Yong-Qi,Liu Zhi-Rong. Intrinsically Disordered Proteins: the New Sequence-Structure-Function Relations[J]. ACTA PHYSICO-CHIMICA SINICA,2010,26(8):2061-2072.
APA Huang Yong-Qi,&Liu Zhi-Rong.(2010).Intrinsically Disordered Proteins: the New Sequence-Structure-Function Relations.ACTA PHYSICO-CHIMICA SINICA,26(8),2061-2072.
MLA Huang Yong-Qi,et al."Intrinsically Disordered Proteins: the New Sequence-Structure-Function Relations".ACTA PHYSICO-CHIMICA SINICA 26.8(2010):2061-2072.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Huang Yong-Qi]'s Articles
[Liu Zhi-Rong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Huang Yong-Qi]'s Articles
[Liu Zhi-Rong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Huang Yong-Qi]'s Articles
[Liu Zhi-Rong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.